Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3891262..3892003 Replicon chromosome
Accession NZ_CP073914
Organism Proteus terrae subsp. cibarius strain SH19PTE4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KF949_RS18250 Protein ID WP_223672638.1
Coordinates 3891262..3891690 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KF949_RS18255 Protein ID WP_075671318.1
Coordinates 3891683..3892003 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF949_RS18235 (KF949_18235) 3887342..3887926 - 585 WP_109419307.1 DNA-3-methyladenine glycosylase I -
KF949_RS18240 (KF949_18240) 3888165..3889070 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
KF949_RS18245 (KF949_18245) 3889080..3891152 + 2073 WP_075671322.1 glycine--tRNA ligase subunit beta -
KF949_RS18250 (KF949_18250) 3891262..3891690 + 429 WP_223672638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF949_RS18255 (KF949_18255) 3891683..3892003 + 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
KF949_RS18260 (KF949_18260) 3892071..3892391 - 321 WP_075671316.1 hypothetical protein -
KF949_RS18265 (KF949_18265) 3892497..3893783 - 1287 WP_075671314.1 DUF3748 domain-containing protein -
KF949_RS18270 (KF949_18270) 3893920..3894537 + 618 WP_006534609.1 trimeric intracellular cation channel family protein -
KF949_RS18275 (KF949_18275) 3894843..3895466 + 624 WP_006534608.1 guanylate kinase -
KF949_RS18280 (KF949_18280) 3895521..3895796 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(15-139)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15862.55 Da        Isoelectric Point: 10.1197

>T200533 WP_223672638.1 NZ_CP073914:3891262-3891690 [Proteus terrae subsp. cibarius]
VVKFTIVKTTTGEVMVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYK
QGSNLFFADGWKKSHLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 429 bp

>T200533 NZ_CP097884:4061926-4062144 [Escherichia coli str. K-12 substr. MG1655]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT200533 WP_075671318.1 NZ_CP073914:3891683-3892003 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT200533 NZ_CP097884:4061526-4061900 [Escherichia coli str. K-12 substr. MG1655]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References