200524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 193984..194543 Replicon chromosome
Accession NZ_CP073910
Organism Sphingobium phenoxybenzoativorans strain Tas13

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KFK14_RS00960 Protein ID WP_212609553.1
Coordinates 194250..194543 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KFK14_RS00955 Protein ID WP_212609552.1
Coordinates 193984..194262 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFK14_RS23940 189854..190327 - 474 WP_246524799.1 hypothetical protein -
KFK14_RS00945 (KFK14_00945) 190547..191623 - 1077 WP_212609550.1 hypothetical protein -
KFK14_RS00950 (KFK14_00950) 191811..193877 + 2067 WP_212609551.1 PBP1A family penicillin-binding protein -
KFK14_RS00955 (KFK14_00955) 193984..194262 + 279 WP_212609552.1 CopG family ribbon-helix-helix protein Antitoxin
KFK14_RS00960 (KFK14_00960) 194250..194543 + 294 WP_212609553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFK14_RS00965 (KFK14_00965) 194604..195092 - 489 WP_212609554.1 hypothetical protein -
KFK14_RS00970 (KFK14_00970) 195503..196213 - 711 WP_246524801.1 SprT family zinc-dependent metalloprotease -
KFK14_RS00975 (KFK14_00975) 196194..196619 - 426 WP_212609555.1 YcgN family cysteine cluster protein -
KFK14_RS00980 (KFK14_00980) 196620..197255 - 636 WP_212609556.1 SCO family protein -
KFK14_RS00985 (KFK14_00985) 197367..197933 + 567 WP_246525002.1 ankyrin repeat domain-containing protein -
KFK14_RS00990 (KFK14_00990) 198075..198566 - 492 WP_070156067.1 MmcB family DNA repair protein -
KFK14_RS00995 (KFK14_00995) 198655..199356 - 702 WP_212609558.1 cell wall hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10845.48 Da        Isoelectric Point: 9.4300

>T200524 WP_212609553.1 NZ_CP073910:194250-194543 [Sphingobium phenoxybenzoativorans]
VPRLIWTPNALADVQRLYRWLLPKDAEAATRAVATIRAGVRILAASPRIGRPVEDMDPDYREKLIDFGNSGYVALYRLDG
DTVAILAVRHQKEAGYP

Download         Length: 294 bp

>T200524 NZ_CP097884:2404511-2404762 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10576.86 Da        Isoelectric Point: 5.2157

>AT200524 WP_212609552.1 NZ_CP073910:193984-194262 [Sphingobium phenoxybenzoativorans]
MTAATSIKLDDALKGRIQNLAEARRRSSHWIMREAIAQYVEREEKREALRQDAMRAWDEYQQTGLHLTLEEADAWLAKLE
AGEDAEPPKCHG

Download         Length: 279 bp

>AT200524 NZ_CP097884:2404759-2405013 [Escherichia coli str. K-12 substr. MG1655]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References