Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4716980..4717815 | Replicon | chromosome |
| Accession | NZ_CP073906 | ||
| Organism | Klebsiella pneumoniae strain HK31 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | KFK82_RS23215 | Protein ID | WP_001559913.1 |
| Coordinates | 4716980..4717357 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5E3EVB5 |
| Locus tag | KFK82_RS23220 | Protein ID | WP_032408847.1 |
| Coordinates | 4717447..4717815 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFK82_RS23175 (4712244) | 4712244..4712510 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| KFK82_RS23180 (4712510) | 4712510..4713182 | + | 673 | Protein_4567 | DUF4400 domain-containing protein | - |
| KFK82_RS23185 (4713193) | 4713193..4714077 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| KFK82_RS23190 (4714276) | 4714276..4714464 | - | 189 | Protein_4569 | transposase | - |
| KFK82_RS23195 (4714481) | 4714481..4715592 | - | 1112 | Protein_4570 | IS3 family transposase | - |
| KFK82_RS23200 (4716044) | 4716044..4716193 | - | 150 | Protein_4571 | restriction endonuclease subunit M | - |
| KFK82_RS23205 (4716278) | 4716278..4716475 | - | 198 | WP_032408848.1 | DUF957 domain-containing protein | - |
| KFK82_RS23210 (4716495) | 4716495..4716983 | - | 489 | WP_001559914.1 | DUF5983 family protein | - |
| KFK82_RS23215 (4716980) | 4716980..4717357 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| KFK82_RS23220 (4717447) | 4717447..4717815 | - | 369 | WP_032408847.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KFK82_RS23225 (4717992) | 4717992..4718213 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| KFK82_RS23230 (4718282) | 4718282..4718758 | - | 477 | WP_032408846.1 | RadC family protein | - |
| KFK82_RS23235 (4718773) | 4718773..4719258 | - | 486 | WP_088607457.1 | antirestriction protein | - |
| KFK82_RS23240 (4719350) | 4719350..4720168 | - | 819 | WP_001559911.1 | DUF932 domain-containing protein | - |
| KFK82_RS23245 (4720268) | 4720268..4720501 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| KFK82_RS23250 (4720580) | 4720580..4721035 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4705679..4735771 | 30092 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T200512 WP_001559913.1 NZ_CP073906:c4717357-4716980 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T200512 NZ_CP097883:c4109002-4108652 [Escherichia coli str. K-12 substr. MG1655]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13682.62 Da Isoelectric Point: 7.8398
>AT200512 WP_032408847.1 NZ_CP073906:c4717815-4717447 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT200512 NZ_CP097883:c4109247-4108996 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E3EVB5 |