Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 693045..693574 Replicon chromosome
Accession NZ_CP073904
Organism Staphylococcus epidermidis strain V1950266

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV55_RS03595 Protein ID WP_001829891.1
Coordinates 693212..693574 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV55_RS03590 Protein ID WP_001829931.1
Coordinates 693045..693215 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV55_RS03565 (KFV55_03560) 688870..689349 + 480 WP_063278489.1 PH domain-containing protein -
KFV55_RS03570 (KFV55_03565) 689342..690847 + 1506 WP_001829976.1 PH domain-containing protein -
KFV55_RS03575 (KFV55_03570) 690834..691343 + 510 WP_001829888.1 PH domain-containing protein -
KFV55_RS03580 (KFV55_03575) 691391..691744 + 354 WP_001829915.1 holo-ACP synthase -
KFV55_RS03585 (KFV55_03580) 691810..692958 + 1149 WP_002468951.1 alanine racemase -
KFV55_RS03590 (KFV55_03585) 693045..693215 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV55_RS03595 (KFV55_03590) 693212..693574 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV55_RS03600 (KFV55_03595) 693920..694921 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV55_RS03605 (KFV55_03600) 695021..695347 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV55_RS03610 (KFV55_03605) 695349..695789 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV55_RS03615 (KFV55_03610) 695803..696573 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200493 WP_001829891.1 NZ_CP073904:693212-693574 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200493 NZ_CP097883:973839-974174 [Escherichia coli str. K-12 substr. MG1655]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200493 WP_001829931.1 NZ_CP073904:693045-693215 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200493 NZ_CP097883:973591-973839 [Escherichia coli str. K-12 substr. MG1655]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References