Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 467375..467845 | Replicon | chromosome |
| Accession | NZ_CP073904 | ||
| Organism | Staphylococcus epidermidis strain V1950266 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV55_RS02355 | Protein ID | WP_001829569.1 |
| Coordinates | 467375..467563 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV55_RS13480 | Protein ID | WP_002438963.1 |
| Coordinates | 467588..467845 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV55_RS02325 (KFV55_02325) | 463856..464056 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| KFV55_RS02330 (KFV55_02330) | 464677..464901 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV55_RS02335 (KFV55_02335) | 464925..465209 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV55_RS02340 (KFV55_02340) | 465308..466054 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV55_RS02345 (KFV55_02345) | 466338..466571 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV55_RS02350 (KFV55_02350) | 466631..467185 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV55_RS02355 (KFV55_02355) | 467375..467563 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV55_RS13480 | 467588..467845 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV55_RS02360 (KFV55_02360) | 468254..468457 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV55_RS02365 (KFV55_02365) | 468449..468685 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV55_RS02370 (KFV55_02370) | 468899..469486 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV55_RS02375 (KFV55_02375) | 469757..470257 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV55_RS02380 (KFV55_02380) | 470843..470998 | + | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV55_RS02385 (KFV55_02385) | 471182..471604 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV55_RS02390 (KFV55_02390) | 471765..472481 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 470843..470998 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200491 WP_001829569.1 NZ_CP073904:c467563-467375 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200491 NZ_CP097883:715187-715483 [Escherichia coli str. K-12 substr. MG1655]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200491 WP_002438963.1 NZ_CP073904:c467845-467588 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200491 NZ_CP097883:715485-715880 [Escherichia coli str. K-12 substr. MG1655]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |