Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2312628..2313098 | Replicon | chromosome |
| Accession | NZ_CP073898 | ||
| Organism | Staphylococcus epidermidis strain V1939586 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV32_RS11245 | Protein ID | WP_001829569.1 |
| Coordinates | 2312910..2313098 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV32_RS13390 | Protein ID | WP_002438963.1 |
| Coordinates | 2312628..2312885 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV32_RS11210 (KFV32_11220) | 2307992..2308708 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| KFV32_RS11215 (KFV32_11225) | 2308869..2309291 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV32_RS11220 (KFV32_11230) | 2309475..2309630 | - | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV32_RS11225 (KFV32_11235) | 2310216..2310716 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV32_RS11230 (KFV32_11240) | 2310987..2311574 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV32_RS11235 (KFV32_11245) | 2311788..2312024 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV32_RS11240 (KFV32_11250) | 2312016..2312219 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV32_RS13390 | 2312628..2312885 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV32_RS11245 (KFV32_11255) | 2312910..2313098 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV32_RS11250 (KFV32_11260) | 2313288..2313842 | + | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV32_RS11255 (KFV32_11265) | 2313902..2314135 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV32_RS11260 (KFV32_11270) | 2314419..2315165 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV32_RS11265 (KFV32_11275) | 2315264..2315548 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV32_RS11270 (KFV32_11280) | 2315572..2315796 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV32_RS11275 (KFV32_11285) | 2316417..2316617 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2309475..2309630 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200485 WP_001829569.1 NZ_CP073898:2312910-2313098 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200485 NZ_CP097882:4023641-4023898 [Escherichia coli str. K-12 substr. MG1655]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200485 WP_002438963.1 NZ_CP073898:2312628-2312885 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200485 NZ_CP097882:4023910-4024455 [Escherichia coli str. K-12 substr. MG1655]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |