Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2312628..2313098 Replicon chromosome
Accession NZ_CP073898
Organism Staphylococcus epidermidis strain V1939586

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV32_RS11245 Protein ID WP_001829569.1
Coordinates 2312910..2313098 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV32_RS13390 Protein ID WP_002438963.1
Coordinates 2312628..2312885 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV32_RS11210 (KFV32_11220) 2307992..2308708 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV32_RS11215 (KFV32_11225) 2308869..2309291 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV32_RS11220 (KFV32_11230) 2309475..2309630 - 156 WP_001829648.1 hypothetical protein -
KFV32_RS11225 (KFV32_11235) 2310216..2310716 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV32_RS11230 (KFV32_11240) 2310987..2311574 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV32_RS11235 (KFV32_11245) 2311788..2312024 + 237 WP_002457224.1 hypothetical protein -
KFV32_RS11240 (KFV32_11250) 2312016..2312219 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV32_RS13390 2312628..2312885 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV32_RS11245 (KFV32_11255) 2312910..2313098 + 189 WP_001829569.1 hypothetical protein Toxin
KFV32_RS11250 (KFV32_11260) 2313288..2313842 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV32_RS11255 (KFV32_11265) 2313902..2314135 - 234 WP_001829664.1 hypothetical protein -
KFV32_RS11260 (KFV32_11270) 2314419..2315165 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV32_RS11265 (KFV32_11275) 2315264..2315548 + 285 WP_001829635.1 hypothetical protein -
KFV32_RS11270 (KFV32_11280) 2315572..2315796 + 225 WP_001829613.1 hypothetical protein -
KFV32_RS11275 (KFV32_11285) 2316417..2316617 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2309475..2309630 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200485 WP_001829569.1 NZ_CP073898:2312910-2313098 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200485 NZ_CP097882:4023641-4023898 [Escherichia coli str. K-12 substr. MG1655]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200485 WP_002438963.1 NZ_CP073898:2312628-2312885 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200485 NZ_CP097882:4023910-4024455 [Escherichia coli str. K-12 substr. MG1655]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References