Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 2098103..2098612 | Replicon | chromosome |
Accession | NZ_CP073898 | ||
Organism | Staphylococcus epidermidis strain V1939586 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | Q5HMD5 |
Locus tag | KFV32_RS10065 | Protein ID | WP_001829980.1 |
Coordinates | 2098103..2098312 (-) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | Q5HMD4 |
Locus tag | KFV32_RS10070 | Protein ID | WP_001829893.1 |
Coordinates | 2098319..2098612 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFV32_RS10045 (KFV32_10055) | 2093681..2095036 | - | 1356 | WP_001832734.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
KFV32_RS10050 (KFV32_10060) | 2095048..2096121 | - | 1074 | WP_001832735.1 | D-alanine--D-alanine ligase | - |
KFV32_RS10055 (KFV32_10065) | 2096512..2097723 | + | 1212 | WP_001829910.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
KFV32_RS10060 (KFV32_10070) | 2097823..2097960 | - | 138 | WP_001829949.1 | Lmo0850 family protein | - |
KFV32_RS10065 (KFV32_10075) | 2098103..2098312 | - | 210 | WP_001829980.1 | heavy-metal-associated domain-containing protein | Toxin |
KFV32_RS10070 (KFV32_10080) | 2098319..2098612 | - | 294 | WP_001829893.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
KFV32_RS10075 (KFV32_10085) | 2098786..2100270 | + | 1485 | WP_002457116.1 | cardiolipin synthase | - |
KFV32_RS10080 (KFV32_10090) | 2100452..2101105 | + | 654 | WP_001829983.1 | HD domain-containing protein | - |
KFV32_RS10085 (KFV32_10095) | 2101211..2102083 | - | 873 | WP_002458703.1 | membrane protein insertase YidC | - |
KFV32_RS10090 (KFV32_10100) | 2102172..2102810 | - | 639 | WP_002505076.1 | thiamine phosphate synthase | - |
KFV32_RS10095 (KFV32_10105) | 2102816..2103604 | - | 789 | WP_001829971.1 | hydroxyethylthiazole kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7987.24 Da Isoelectric Point: 7.0080
>T200484 WP_001829980.1 NZ_CP073898:c2098312-2098103 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
Download Length: 210 bp
>T200484 NZ_CP097882:3977854-3978195 [Escherichia coli str. K-12 substr. MG1655]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11070.65 Da Isoelectric Point: 5.5778
>AT200484 WP_001829893.1 NZ_CP073898:c2098612-2098319 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
Download Length: 294 bp
>AT200484 NZ_CP097882:c3977859-3977783 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HWU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0N1EPA7 |