Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2098103..2098612 Replicon chromosome
Accession NZ_CP073898
Organism Staphylococcus epidermidis strain V1939586

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV32_RS10065 Protein ID WP_001829980.1
Coordinates 2098103..2098312 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV32_RS10070 Protein ID WP_001829893.1
Coordinates 2098319..2098612 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV32_RS10045 (KFV32_10055) 2093681..2095036 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV32_RS10050 (KFV32_10060) 2095048..2096121 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV32_RS10055 (KFV32_10065) 2096512..2097723 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV32_RS10060 (KFV32_10070) 2097823..2097960 - 138 WP_001829949.1 Lmo0850 family protein -
KFV32_RS10065 (KFV32_10075) 2098103..2098312 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV32_RS10070 (KFV32_10080) 2098319..2098612 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV32_RS10075 (KFV32_10085) 2098786..2100270 + 1485 WP_002457116.1 cardiolipin synthase -
KFV32_RS10080 (KFV32_10090) 2100452..2101105 + 654 WP_001829983.1 HD domain-containing protein -
KFV32_RS10085 (KFV32_10095) 2101211..2102083 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV32_RS10090 (KFV32_10100) 2102172..2102810 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV32_RS10095 (KFV32_10105) 2102816..2103604 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200484 WP_001829980.1 NZ_CP073898:c2098312-2098103 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200484 NZ_CP097882:3977854-3978195 [Escherichia coli str. K-12 substr. MG1655]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200484 WP_001829893.1 NZ_CP073898:c2098612-2098319 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200484 NZ_CP097882:c3977859-3977783 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References