Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 690497..691026 Replicon chromosome
Accession NZ_CP073895
Organism Staphylococcus epidermidis strain V1937538

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV38_RS03505 Protein ID WP_001829891.1
Coordinates 690664..691026 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV38_RS03500 Protein ID WP_001829931.1
Coordinates 690497..690667 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV38_RS03475 (KFV38_03475) 686322..686801 + 480 WP_063278489.1 PH domain-containing protein -
KFV38_RS03480 (KFV38_03480) 686794..688299 + 1506 WP_001829976.1 PH domain-containing protein -
KFV38_RS03485 (KFV38_03485) 688286..688795 + 510 WP_001829888.1 PH domain-containing protein -
KFV38_RS03490 (KFV38_03490) 688843..689196 + 354 WP_001829915.1 holo-ACP synthase -
KFV38_RS03495 (KFV38_03495) 689262..690410 + 1149 WP_002468951.1 alanine racemase -
KFV38_RS03500 (KFV38_03500) 690497..690667 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV38_RS03505 (KFV38_03505) 690664..691026 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV38_RS03510 (KFV38_03510) 691372..692373 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV38_RS03515 (KFV38_03515) 692473..692799 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV38_RS03520 (KFV38_03520) 692801..693241 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV38_RS03525 (KFV38_03525) 693255..694025 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200478 WP_001829891.1 NZ_CP073895:690664-691026 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200478 NZ_CP097882:2598325-2598432 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200478 WP_001829931.1 NZ_CP073895:690497-690667 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200478 NZ_CP097882:c2598278-2598212 [Escherichia coli str. K-12 substr. MG1655]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References