Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 679314..679823 Replicon chromosome
Accession NZ_CP073895
Organism Staphylococcus epidermidis strain V1937538

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV38_RS03445 Protein ID WP_001829980.1
Coordinates 679614..679823 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV38_RS03440 Protein ID WP_001829893.1
Coordinates 679314..679607 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV38_RS03415 (KFV38_03415) 674322..675110 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV38_RS03420 (KFV38_03420) 675116..675754 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV38_RS03425 (KFV38_03425) 675843..676715 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV38_RS03430 (KFV38_03430) 676821..677474 - 654 WP_001829983.1 HD domain-containing protein -
KFV38_RS03435 (KFV38_03435) 677656..679140 - 1485 WP_002457116.1 cardiolipin synthase -
KFV38_RS03440 (KFV38_03440) 679314..679607 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV38_RS03445 (KFV38_03445) 679614..679823 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV38_RS03450 (KFV38_03450) 679966..680103 + 138 WP_001829949.1 Lmo0850 family protein -
KFV38_RS03455 (KFV38_03455) 680203..681414 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV38_RS03460 (KFV38_03460) 681805..682878 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV38_RS03465 (KFV38_03465) 682890..684245 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200477 WP_001829980.1 NZ_CP073895:679614-679823 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200477 NZ_CP097882:2597790-2597897 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200477 WP_001829893.1 NZ_CP073895:679314-679607 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200477 NZ_CP097882:c2597743-2597677 [Escherichia coli str. K-12 substr. MG1655]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References