Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 464827..465297 Replicon chromosome
Accession NZ_CP073895
Organism Staphylococcus epidermidis strain V1937538

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV38_RS02265 Protein ID WP_001829569.1
Coordinates 464827..465015 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV38_RS13420 Protein ID WP_002438963.1
Coordinates 465040..465297 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV38_RS02235 (KFV38_02235) 461308..461508 + 201 WP_001829681.1 cold-shock protein -
KFV38_RS02240 (KFV38_02240) 462129..462353 - 225 WP_001829613.1 hypothetical protein -
KFV38_RS02245 (KFV38_02245) 462377..462661 - 285 WP_001829635.1 hypothetical protein -
KFV38_RS02250 (KFV38_02250) 462760..463506 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV38_RS02255 (KFV38_02255) 463790..464023 + 234 WP_001829664.1 hypothetical protein -
KFV38_RS02260 (KFV38_02260) 464083..464637 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV38_RS02265 (KFV38_02265) 464827..465015 - 189 WP_001829569.1 hypothetical protein Toxin
KFV38_RS13420 465040..465297 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV38_RS02270 (KFV38_02270) 465706..465909 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV38_RS02275 (KFV38_02275) 465901..466137 - 237 WP_002457224.1 hypothetical protein -
KFV38_RS02280 (KFV38_02280) 466351..466938 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV38_RS02285 (KFV38_02285) 467209..467709 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV38_RS02290 (KFV38_02290) 468295..468450 + 156 WP_001829648.1 hypothetical protein -
KFV38_RS02295 (KFV38_02295) 468634..469056 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV38_RS02300 (KFV38_02300) 469217..469933 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446615..470556 23941
- flank IS/Tn - - 468295..468450 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200476 WP_001829569.1 NZ_CP073895:c465015-464827 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200476 NZ_CP097882:c2358712-2358536 [Escherichia coli str. K-12 substr. MG1655]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200476 WP_002438963.1 NZ_CP073895:c465297-465040 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200476 NZ_CP097882:c2358490-2358074 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References