Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 464827..465297 | Replicon | chromosome |
| Accession | NZ_CP073895 | ||
| Organism | Staphylococcus epidermidis strain V1937538 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV38_RS02265 | Protein ID | WP_001829569.1 |
| Coordinates | 464827..465015 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV38_RS13420 | Protein ID | WP_002438963.1 |
| Coordinates | 465040..465297 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV38_RS02235 (KFV38_02235) | 461308..461508 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| KFV38_RS02240 (KFV38_02240) | 462129..462353 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV38_RS02245 (KFV38_02245) | 462377..462661 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV38_RS02250 (KFV38_02250) | 462760..463506 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV38_RS02255 (KFV38_02255) | 463790..464023 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV38_RS02260 (KFV38_02260) | 464083..464637 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV38_RS02265 (KFV38_02265) | 464827..465015 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV38_RS13420 | 465040..465297 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV38_RS02270 (KFV38_02270) | 465706..465909 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV38_RS02275 (KFV38_02275) | 465901..466137 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV38_RS02280 (KFV38_02280) | 466351..466938 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV38_RS02285 (KFV38_02285) | 467209..467709 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV38_RS02290 (KFV38_02290) | 468295..468450 | + | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV38_RS02295 (KFV38_02295) | 468634..469056 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV38_RS02300 (KFV38_02300) | 469217..469933 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 446615..470556 | 23941 | |
| - | flank | IS/Tn | - | - | 468295..468450 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200476 WP_001829569.1 NZ_CP073895:c465015-464827 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200476 NZ_CP097882:c2358712-2358536 [Escherichia coli str. K-12 substr. MG1655]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200476 WP_002438963.1 NZ_CP073895:c465297-465040 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200476 NZ_CP097882:c2358490-2358074 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |