Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2248071..2248541 Replicon chromosome
Accession NZ_CP073893
Organism Staphylococcus epidermidis strain V1936703

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV49_RS11005 Protein ID WP_001829569.1
Coordinates 2248353..2248541 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV49_RS13465 Protein ID WP_002438963.1
Coordinates 2248071..2248328 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV49_RS10970 (KFV49_10980) 2243435..2244151 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV49_RS10975 (KFV49_10985) 2244312..2244734 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV49_RS10980 (KFV49_10990) 2244918..2245055 - 138 WP_162161215.1 hypothetical protein -
KFV49_RS10985 (KFV49_10995) 2245659..2246159 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV49_RS10990 (KFV49_11000) 2246430..2247017 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV49_RS10995 (KFV49_11005) 2247231..2247467 + 237 WP_002457224.1 hypothetical protein -
KFV49_RS11000 (KFV49_11010) 2247459..2247662 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV49_RS13465 2248071..2248328 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV49_RS11005 (KFV49_11015) 2248353..2248541 + 189 WP_001829569.1 hypothetical protein Toxin
KFV49_RS11010 (KFV49_11020) 2248731..2249285 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV49_RS11015 (KFV49_11025) 2249345..2249578 - 234 WP_001829664.1 hypothetical protein -
KFV49_RS11020 (KFV49_11030) 2249862..2250608 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV49_RS11025 (KFV49_11035) 2250707..2250991 + 285 WP_001829635.1 hypothetical protein -
KFV49_RS11030 (KFV49_11040) 2251015..2251239 + 225 WP_001829613.1 hypothetical protein -
KFV49_RS11035 (KFV49_11045) 2251860..2252060 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2239043..2266753 27710
- flank IS/Tn - - 2244918..2245073 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200475 WP_001829569.1 NZ_CP073893:2248353-2248541 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200475 NZ_CP097882:2275822-2277144 [Escherichia coli str. K-12 substr. MG1655]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200475 WP_002438963.1 NZ_CP073893:2248071-2248328 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200475 NZ_CP097882:2275556-2275822 [Escherichia coli str. K-12 substr. MG1655]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References