Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2033545..2034054 Replicon chromosome
Accession NZ_CP073893
Organism Staphylococcus epidermidis strain V1936703

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV49_RS09825 Protein ID WP_001829980.1
Coordinates 2033545..2033754 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV49_RS09830 Protein ID WP_001829893.1
Coordinates 2033761..2034054 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV49_RS09805 (KFV49_09815) 2029123..2030478 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV49_RS09810 (KFV49_09820) 2030490..2031563 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV49_RS09815 (KFV49_09825) 2031954..2033165 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV49_RS09820 (KFV49_09830) 2033265..2033402 - 138 WP_001829949.1 Lmo0850 family protein -
KFV49_RS09825 (KFV49_09835) 2033545..2033754 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV49_RS09830 (KFV49_09840) 2033761..2034054 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV49_RS09835 (KFV49_09845) 2034228..2035712 + 1485 WP_002457116.1 cardiolipin synthase -
KFV49_RS09840 (KFV49_09850) 2035894..2036547 + 654 WP_001829983.1 HD domain-containing protein -
KFV49_RS09845 (KFV49_09855) 2036653..2037525 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV49_RS09850 (KFV49_09860) 2037614..2038252 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV49_RS09855 (KFV49_09865) 2038258..2039046 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200474 WP_001829980.1 NZ_CP073893:c2033754-2033545 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200474 NZ_CP097882:2222365-2222652 [Escherichia coli str. K-12 substr. MG1655]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200474 WP_001829893.1 NZ_CP073893:c2034054-2033761 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200474 NZ_CP097882:2222126-2222365 [Escherichia coli str. K-12 substr. MG1655]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References