Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1893049..1893674 Replicon chromosome
Accession NZ_CP073893
Organism Staphylococcus epidermidis strain V1936703

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV49_RS09110 Protein ID WP_002504557.1
Coordinates 1893049..1893444 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV49_RS09115 Protein ID WP_002504558.1
Coordinates 1893444..1893674 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV49_RS09075 (KFV49_09085) 1888717..1889121 + 405 WP_002504535.1 YolD-like family protein -
KFV49_RS13445 1889204..1889338 + 135 WP_002504536.1 hypothetical protein -
KFV49_RS09080 (KFV49_09090) 1889369..1890010 - 642 WP_002504537.1 hypothetical protein -
KFV49_RS09085 (KFV49_09095) 1890116..1890838 - 723 WP_002504538.1 hypothetical protein -
KFV49_RS09090 (KFV49_09100) 1890947..1891747 - 801 WP_000686449.1 metallophosphoesterase -
KFV49_RS09095 (KFV49_09105) 1891751..1892245 - 495 WP_010959224.1 hypothetical protein -
KFV49_RS09100 (KFV49_09110) 1892302..1892571 - 270 WP_000755772.1 hypothetical protein -
KFV49_RS09105 (KFV49_09115) 1892555..1892746 - 192 WP_002504556.1 hypothetical protein -
KFV49_RS09110 (KFV49_09120) 1893049..1893444 - 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV49_RS09115 (KFV49_09125) 1893444..1893674 - 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV49_RS09120 (KFV49_09130) 1893837..1894355 - 519 WP_002504559.1 metallophosphoesterase -
KFV49_RS09125 (KFV49_09135) 1894355..1895005 - 651 WP_002504560.1 hypothetical protein -
KFV49_RS09130 (KFV49_09140) 1895005..1895322 - 318 WP_002504561.1 hypothetical protein -
KFV49_RS09135 (KFV49_09145) 1895315..1896040 - 726 WP_010959229.1 metallophosphoesterase -
KFV49_RS09140 (KFV49_09150) 1896040..1896261 - 222 WP_002504563.1 hypothetical protein -
KFV49_RS09145 (KFV49_09155) 1896281..1896457 - 177 WP_002504564.1 hypothetical protein -
KFV49_RS09150 (KFV49_09160) 1896450..1896992 - 543 WP_002504565.1 hypothetical protein -
KFV49_RS09155 (KFV49_09165) 1897008..1897280 - 273 WP_002504566.1 hypothetical protein -
KFV49_RS09160 (KFV49_09170) 1897306..1897461 - 156 WP_002504567.1 transcriptional activator RinB -
KFV49_RS09165 (KFV49_09175) 1897458..1897742 - 285 WP_002504568.1 hypothetical protein -
KFV49_RS09170 (KFV49_09180) 1897758..1897943 - 186 WP_001187008.1 hypothetical protein -
KFV49_RS09175 (KFV49_09185) 1897928..1898107 - 180 WP_002504569.1 hypothetical protein -
KFV49_RS09180 (KFV49_09190) 1898123..1898605 - 483 WP_002504570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') - 1866065..1924946 58881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200472 WP_002504557.1 NZ_CP073893:c1893444-1893049 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200472 NZ_CP097882:c1791205-1790831 [Escherichia coli str. K-12 substr. MG1655]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200472 WP_002504558.1 NZ_CP073893:c1893674-1893444 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200472 NZ_CP097882:c1791662-1791294 [Escherichia coli str. K-12 substr. MG1655]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References