Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 467391..467861 Replicon chromosome
Accession NZ_CP073890
Organism Staphylococcus epidermidis strain V1933793

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV31_RS02355 Protein ID WP_001829569.1
Coordinates 467391..467579 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV31_RS13540 Protein ID WP_002438963.1
Coordinates 467604..467861 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV31_RS02325 (KFV31_02325) 463872..464072 + 201 WP_001829681.1 cold-shock protein -
KFV31_RS02330 (KFV31_02330) 464693..464917 - 225 WP_001829613.1 hypothetical protein -
KFV31_RS02335 (KFV31_02335) 464941..465225 - 285 WP_001829635.1 hypothetical protein -
KFV31_RS02340 (KFV31_02340) 465324..466070 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV31_RS02345 (KFV31_02345) 466354..466587 + 234 WP_001829664.1 hypothetical protein -
KFV31_RS02350 (KFV31_02350) 466647..467201 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV31_RS02355 (KFV31_02355) 467391..467579 - 189 WP_001829569.1 hypothetical protein Toxin
KFV31_RS13540 467604..467861 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV31_RS02360 (KFV31_02360) 468271..468474 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV31_RS02365 (KFV31_02365) 468466..468702 - 237 WP_002457224.1 hypothetical protein -
KFV31_RS02370 (KFV31_02370) 468916..469503 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV31_RS02375 (KFV31_02375) 469774..470274 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV31_RS02380 (KFV31_02380) 470878..471015 + 138 WP_162161215.1 hypothetical protein -
KFV31_RS02385 (KFV31_02385) 471199..471621 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV31_RS02390 (KFV31_02390) 471782..472498 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 470860..471015 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200466 WP_001829569.1 NZ_CP073890:c467579-467391 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200466 NZ_CP097882:842908-843315 [Escherichia coli str. K-12 substr. MG1655]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200466 WP_002438963.1 NZ_CP073890:c467861-467604 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200466 NZ_CP097882:842661-842927 [Escherichia coli str. K-12 substr. MG1655]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References