Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 691918..692447 Replicon chromosome
Accession NZ_CP073887
Organism Staphylococcus epidermidis strain V1933625

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV30_RS03590 Protein ID WP_001829891.1
Coordinates 692085..692447 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV30_RS03585 Protein ID WP_001829931.1
Coordinates 691918..692088 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV30_RS03560 (KFV30_03560) 687743..688222 + 480 WP_063278489.1 PH domain-containing protein -
KFV30_RS03565 (KFV30_03565) 688215..689720 + 1506 WP_001829976.1 PH domain-containing protein -
KFV30_RS03570 (KFV30_03570) 689707..690216 + 510 WP_001829888.1 PH domain-containing protein -
KFV30_RS03575 (KFV30_03575) 690264..690617 + 354 WP_001829915.1 holo-ACP synthase -
KFV30_RS03580 (KFV30_03580) 690683..691831 + 1149 WP_002468951.1 alanine racemase -
KFV30_RS03585 (KFV30_03585) 691918..692088 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV30_RS03590 (KFV30_03590) 692085..692447 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV30_RS03595 (KFV30_03595) 692793..693794 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV30_RS03600 (KFV30_03600) 693894..694220 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV30_RS03605 (KFV30_03605) 694222..694662 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV30_RS03610 (KFV30_03610) 694676..695446 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200463 WP_001829891.1 NZ_CP073887:692085-692447 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200463 NZ_CP097882:c606394-605930 [Escherichia coli str. K-12 substr. MG1655]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200463 WP_001829931.1 NZ_CP073887:691918-692088 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200463 NZ_CP097882:c606729-606394 [Escherichia coli str. K-12 substr. MG1655]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References