Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/-
Location 4420677..4421272 Replicon chromosome
Accession CP009789
Organism Escherichia coli K-12 strain ER3413

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag ER3413_4370 Protein ID AIZ54048.1
Coordinates 4420922..4421272 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag ER3413_4369 Protein ID AIZ54046.1
Coordinates 4420677..4420928 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER3413_4367 4416342..4420121 + 3780 AIZ54044.1 translocation and assembly module for autotransporter export, inner membrane subunit -
ER3413_4368 4420124..4420465 + 342 AIZ54045.1 GGCT-like protein -
ER3413_4369 4420677..4420928 + 252 AIZ54046.1 antitoxin of the ChpBS toxin-antitoxin system Antitoxin
ER3413_4370 4420922..4421272 + 351 AIZ54048.1 toxin of the ChpB-ChpS toxin-antitoxin system Toxin
ER3413_4371 4421352..4421882 - 531 AIZ54049.1 inorganic pyrophosphatase -
ER3413_4372 4422192..4423148 + 957 AIZ54050.1 galactofuranose binding proteint: periplasmic-binding component of ABC superfamily -
ER3413_4373 4423288..4424790 + 1503 AIZ54051.1 putative sugar transporter subunit: ATP-binding component of ABC superfamily -
ER3413_4374 4424801..4425826 + 1026 AIZ54052.1 putative sugar transporter subunit: membrane component of ABC superfamily -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T20046 AIZ54048.1 CP009789:4420922-4421272 [Escherichia coli K-12]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T20046 CP009789:4420922-4421272 [Escherichia coli K-12]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT20046 AIZ54046.1 CP009789:4420677-4420928 [Escherichia coli K-12]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT20046 CP009789:4420677-4420928 [Escherichia coli K-12]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References