Detailed information of TA system TA020046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/-
• Location: 4420677..4421272
• Replicon: chromosome
• Accession: CP009789
• Organism: Escherichia coli K-12 strain ER3413

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: ER3413_4370
• Protein ID: AIZ54048.1
• Coordinates: 4420922..4421272 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: ER3413_4369
• Protein ID: AIZ54046.1
• Coordinates: 4420677..4420928 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER3413_4367	4416342..4420121	+	3780	AIZ54044.1	translocation and assembly module for autotransporter export, inner membrane subunit	-
ER3413_4368	4420124..4420465	+	342	AIZ54045.1	GGCT-like protein	-
ER3413_4369	4420677..4420928	+	252	AIZ54046.1	antitoxin of the ChpBS toxin-antitoxin system	Antitoxin
ER3413_4370	4420922..4421272	+	351	AIZ54048.1	toxin of the ChpB-ChpS toxin-antitoxin system	Toxin
ER3413_4371	4421352..4421882	-	531	AIZ54049.1	inorganic pyrophosphatase	-
ER3413_4372	4422192..4423148	+	957	AIZ54050.1	galactofuranose binding proteint: periplasmic-binding component of ABC superfamily	-
ER3413_4373	4423288..4424790	+	1503	AIZ54051.1	putative sugar transporter subunit: ATP-binding component of ABC superfamily	-
ER3413_4374	4424801..4425826	+	1026	AIZ54052.1	putative sugar transporter subunit: membrane component of ABC superfamily	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12492.40 Da
• Isoelectric Point: 5.5572

>T20046 AIZ54048.1 CP009789:4420922-4421272 [Escherichia coli K-12]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T20046 CP009789:4420922-4421272 [Escherichia coli K-12]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.58 Da
• Isoelectric Point: 4.4201

>AT20046 AIZ54046.1 CP009789:4420677-4420928 [Escherichia coli K-12]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT20046 CP009789:4420677-4420928 [Escherichia coli K-12]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA