Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 406157..406686 Replicon chromosome
Accession NZ_CP073883
Organism Staphylococcus epidermidis strain B1287175

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV54_RS02110 Protein ID WP_001829891.1
Coordinates 406324..406686 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV54_RS02105 Protein ID WP_001829931.1
Coordinates 406157..406327 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV54_RS02080 (KFV54_02080) 401982..402461 + 480 WP_063278489.1 PH domain-containing protein -
KFV54_RS02085 (KFV54_02085) 402454..403959 + 1506 WP_001829976.1 PH domain-containing protein -
KFV54_RS02090 (KFV54_02090) 403946..404455 + 510 WP_001829888.1 PH domain-containing protein -
KFV54_RS02095 (KFV54_02095) 404503..404856 + 354 WP_001829915.1 holo-ACP synthase -
KFV54_RS02100 (KFV54_02100) 404922..406070 + 1149 WP_002468951.1 alanine racemase -
KFV54_RS02105 (KFV54_02105) 406157..406327 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV54_RS02110 (KFV54_02110) 406324..406686 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV54_RS02115 (KFV54_02115) 407032..408033 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV54_RS02120 (KFV54_02120) 408133..408459 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV54_RS02125 (KFV54_02125) 408461..408901 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV54_RS02130 (KFV54_02130) 408915..409685 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200458 WP_001829891.1 NZ_CP073883:406324-406686 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200458 NZ_CP097881:3907055-3907396 [Escherichia coli str. K-12 substr. MG1655]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200458 WP_001829931.1 NZ_CP073883:406157-406327 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200458 NZ_CP097881:c3907060-3906984 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References