Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 394974..395483 Replicon chromosome
Accession NZ_CP073883
Organism Staphylococcus epidermidis strain B1287175

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV54_RS02050 Protein ID WP_001829980.1
Coordinates 395274..395483 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV54_RS02045 Protein ID WP_001829893.1
Coordinates 394974..395267 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV54_RS02020 (KFV54_02020) 389982..390770 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV54_RS02025 (KFV54_02025) 390776..391414 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV54_RS02030 (KFV54_02030) 391503..392375 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV54_RS02035 (KFV54_02035) 392481..393134 - 654 WP_001829983.1 HD domain-containing protein -
KFV54_RS02040 (KFV54_02040) 393316..394800 - 1485 WP_002457116.1 cardiolipin synthase -
KFV54_RS02045 (KFV54_02045) 394974..395267 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV54_RS02050 (KFV54_02050) 395274..395483 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV54_RS02055 (KFV54_02055) 395626..395763 + 138 WP_001829949.1 Lmo0850 family protein -
KFV54_RS02060 (KFV54_02060) 395863..397074 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV54_RS02065 (KFV54_02065) 397465..398538 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV54_RS02070 (KFV54_02070) 398550..399905 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200457 WP_001829980.1 NZ_CP073883:395274-395483 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200457 NZ_CP097881:3599005-3599283 [Escherichia coli str. K-12 substr. MG1655]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200457 WP_001829893.1 NZ_CP073883:394974-395267 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200457 NZ_CP097881:3598742-3599002 [Escherichia coli str. K-12 substr. MG1655]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References