Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 180487..180957 | Replicon | chromosome |
| Accession | NZ_CP073883 | ||
| Organism | Staphylococcus epidermidis strain B1287175 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV54_RS00870 | Protein ID | WP_001829569.1 |
| Coordinates | 180487..180675 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV54_RS13420 | Protein ID | WP_002438963.1 |
| Coordinates | 180700..180957 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV54_RS00840 (KFV54_00840) | 176968..177168 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| KFV54_RS00845 (KFV54_00845) | 177789..178013 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV54_RS00850 (KFV54_00850) | 178037..178321 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV54_RS00855 (KFV54_00855) | 178420..179166 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV54_RS00860 (KFV54_00860) | 179450..179683 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV54_RS00865 (KFV54_00865) | 179743..180297 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV54_RS00870 (KFV54_00870) | 180487..180675 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV54_RS13420 | 180700..180957 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV54_RS00875 (KFV54_00875) | 181366..181569 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV54_RS00880 (KFV54_00880) | 181561..181797 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV54_RS00885 (KFV54_00885) | 182011..182598 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV54_RS00890 (KFV54_00890) | 182869..183369 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV54_RS00895 (KFV54_00895) | 183973..184110 | + | 138 | WP_162161215.1 | hypothetical protein | - |
| KFV54_RS00900 (KFV54_00900) | 184294..184716 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV54_RS00905 (KFV54_00905) | 184877..185593 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 176968..189985 | 13017 | |
| - | flank | IS/Tn | - | - | 183955..184110 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200456 WP_001829569.1 NZ_CP073883:c180675-180487 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200456 NZ_CP097881:c3592943-3592545 [Escherichia coli str. K-12 substr. MG1655]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200456 WP_002438963.1 NZ_CP073883:c180957-180700 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200456 NZ_CP097881:c3593239-3592946 [Escherichia coli str. K-12 substr. MG1655]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |