200453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 692962..693491 Replicon chromosome
Accession NZ_CP073881
Organism Staphylococcus epidermidis strain B1286247

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV53_RS03555 Protein ID WP_001829891.1
Coordinates 693129..693491 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV53_RS03550 Protein ID WP_001829931.1
Coordinates 692962..693132 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV53_RS03525 (KFV53_03525) 688787..689266 + 480 WP_063278489.1 PH domain-containing protein -
KFV53_RS03530 (KFV53_03530) 689259..690764 + 1506 WP_001829976.1 PH domain-containing protein -
KFV53_RS03535 (KFV53_03535) 690751..691260 + 510 WP_001829888.1 PH domain-containing protein -
KFV53_RS03540 (KFV53_03540) 691308..691661 + 354 WP_001829915.1 holo-ACP synthase -
KFV53_RS03545 (KFV53_03545) 691727..692875 + 1149 WP_002468951.1 alanine racemase -
KFV53_RS03550 (KFV53_03550) 692962..693132 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV53_RS03555 (KFV53_03555) 693129..693491 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV53_RS03560 (KFV53_03560) 693837..694838 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV53_RS03565 (KFV53_03565) 694938..695264 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV53_RS03570 (KFV53_03570) 695266..695706 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV53_RS03575 (KFV53_03575) 695720..696490 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200453 WP_001829891.1 NZ_CP073881:693129-693491 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200453 NZ_CP097881:2574015-2574122 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200453 WP_001829931.1 NZ_CP073881:692962-693132 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200453 NZ_CP097881:c2573965-2573902 [Escherichia coli str. K-12 substr. MG1655]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References