200452

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 681779..682288 Replicon chromosome
Accession NZ_CP073881
Organism Staphylococcus epidermidis strain B1286247

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV53_RS03495 Protein ID WP_001829980.1
Coordinates 682079..682288 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV53_RS03490 Protein ID WP_001829893.1
Coordinates 681779..682072 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV53_RS03465 (KFV53_03465) 676787..677575 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV53_RS03470 (KFV53_03470) 677581..678219 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV53_RS03475 (KFV53_03475) 678308..679180 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV53_RS03480 (KFV53_03480) 679286..679939 - 654 WP_001829983.1 HD domain-containing protein -
KFV53_RS03485 (KFV53_03485) 680121..681605 - 1485 WP_002457116.1 cardiolipin synthase -
KFV53_RS03490 (KFV53_03490) 681779..682072 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV53_RS03495 (KFV53_03495) 682079..682288 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV53_RS03500 (KFV53_03500) 682431..682568 + 138 WP_001829949.1 Lmo0850 family protein -
KFV53_RS03505 (KFV53_03505) 682668..683879 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV53_RS03510 (KFV53_03510) 684270..685343 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV53_RS03515 (KFV53_03515) 685355..686710 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200452 WP_001829980.1 NZ_CP073881:682079-682288 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200452 NZ_CP097881:2573480-2573587 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200452 WP_001829893.1 NZ_CP073881:681779-682072 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200452 NZ_CP097881:c2573433-2573367 [Escherichia coli str. K-12 substr. MG1655]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References