Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 467292..467762 Replicon chromosome
Accession NZ_CP073881
Organism Staphylococcus epidermidis strain B1286247

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV53_RS02315 Protein ID WP_001829569.1
Coordinates 467292..467480 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV53_RS13345 Protein ID WP_002438963.1
Coordinates 467505..467762 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV53_RS02285 (KFV53_02285) 463773..463973 + 201 WP_001829681.1 cold-shock protein -
KFV53_RS02290 (KFV53_02290) 464594..464818 - 225 WP_001829613.1 hypothetical protein -
KFV53_RS02295 (KFV53_02295) 464842..465126 - 285 WP_001829635.1 hypothetical protein -
KFV53_RS02300 (KFV53_02300) 465225..465971 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV53_RS02305 (KFV53_02305) 466255..466488 + 234 WP_001829664.1 hypothetical protein -
KFV53_RS02310 (KFV53_02310) 466548..467102 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV53_RS02315 (KFV53_02315) 467292..467480 - 189 WP_001829569.1 hypothetical protein Toxin
KFV53_RS13345 467505..467762 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV53_RS02320 (KFV53_02320) 468171..468374 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV53_RS02325 (KFV53_02325) 468366..468602 - 237 WP_002457224.1 hypothetical protein -
KFV53_RS02330 (KFV53_02330) 468816..469403 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV53_RS02335 (KFV53_02335) 469674..470174 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV53_RS02340 (KFV53_02340) 470778..470915 + 138 WP_162161215.1 hypothetical protein -
KFV53_RS02345 (KFV53_02345) 471099..471521 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV53_RS02350 (KFV53_02350) 471682..472398 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 470760..470915 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200451 WP_001829569.1 NZ_CP073881:c467480-467292 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200451 NZ_CP097881:2572945-2573052 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200451 WP_002438963.1 NZ_CP073881:c467762-467505 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200451 NZ_CP097881:c2572898-2572832 [Escherichia coli str. K-12 substr. MG1655]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References