200447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 681848..682357 Replicon chromosome
Accession NZ_CP073878
Organism Staphylococcus epidermidis strain B1285228

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV29_RS03620 Protein ID WP_001829980.1
Coordinates 682148..682357 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV29_RS03615 Protein ID WP_001829893.1
Coordinates 681848..682141 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV29_RS03590 (KFV29_03590) 676856..677644 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV29_RS03595 (KFV29_03595) 677650..678288 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV29_RS03600 (KFV29_03600) 678377..679249 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV29_RS03605 (KFV29_03605) 679355..680008 - 654 WP_001829983.1 HD domain-containing protein -
KFV29_RS03610 (KFV29_03610) 680190..681674 - 1485 WP_002457116.1 cardiolipin synthase -
KFV29_RS03615 (KFV29_03615) 681848..682141 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV29_RS03620 (KFV29_03620) 682148..682357 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV29_RS03625 (KFV29_03625) 682500..682637 + 138 WP_001829949.1 Lmo0850 family protein -
KFV29_RS03630 (KFV29_03630) 682737..683948 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV29_RS03635 (KFV29_03635) 684339..685412 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV29_RS03640 (KFV29_03640) 685424..686779 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200447 WP_001829980.1 NZ_CP073878:682148-682357 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200447 NZ_CP097881:1959744-1959847 [Escherichia coli str. K-12 substr. MG1655]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200447 WP_001829893.1 NZ_CP073878:681848-682141 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200447 NZ_CP097881:c1959885-1959614 [Escherichia coli str. K-12 substr. MG1655]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References