Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 467361..467831 | Replicon | chromosome |
| Accession | NZ_CP073878 | ||
| Organism | Staphylococcus epidermidis strain B1285228 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV29_RS02440 | Protein ID | WP_001829569.1 |
| Coordinates | 467361..467549 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV29_RS13435 | Protein ID | WP_002438963.1 |
| Coordinates | 467574..467831 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV29_RS02410 (KFV29_02410) | 463842..464042 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| KFV29_RS02415 (KFV29_02415) | 464663..464887 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV29_RS02420 (KFV29_02420) | 464911..465195 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV29_RS02425 (KFV29_02425) | 465294..466040 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV29_RS02430 (KFV29_02430) | 466324..466557 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV29_RS02435 (KFV29_02435) | 466617..467171 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV29_RS02440 (KFV29_02440) | 467361..467549 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV29_RS13435 | 467574..467831 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV29_RS02445 (KFV29_02445) | 468240..468443 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV29_RS02450 (KFV29_02450) | 468435..468671 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV29_RS02455 (KFV29_02455) | 468885..469472 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV29_RS02460 (KFV29_02460) | 469743..470243 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV29_RS02465 (KFV29_02465) | 470829..470984 | + | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV29_RS02470 (KFV29_02470) | 471168..471590 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV29_RS02475 (KFV29_02475) | 471751..472467 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 470829..470984 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200446 WP_001829569.1 NZ_CP073878:c467549-467361 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200446 NZ_CP097881:c1806158-1805784 [Escherichia coli str. K-12 substr. MG1655]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200446 WP_002438963.1 NZ_CP073878:c467831-467574 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200446 NZ_CP097881:c1806615-1806247 [Escherichia coli str. K-12 substr. MG1655]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |