Detailed information of TA system TA200445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2245468..2245938
• Replicon: chromosome
• Accession: NZ_CP073876
• Organism: Staphylococcus epidermidis strain B1285135

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: KFV37_RS10985
• Protein ID: WP_001829569.1
• Coordinates: 2245750..2245938 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: KFV37_RS13395
• Protein ID: WP_002438963.1
• Coordinates: 2245468..2245725 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFV37_RS10950 (KFV37_10990)	2240832..2241548	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
KFV37_RS10955 (KFV37_10995)	2241709..2242131	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
KFV37_RS10960 (KFV37_11000)	2242315..2242470	-	156	WP_001829648.1	hypothetical protein	-
KFV37_RS10965 (KFV37_11005)	2243056..2243556	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
KFV37_RS10970 (KFV37_11010)	2243827..2244414	-	588	WP_001829615.1	histidine phosphatase family protein	-
KFV37_RS10975 (KFV37_11015)	2244628..2244864	+	237	WP_002457224.1	hypothetical protein	-
KFV37_RS10980 (KFV37_11020)	2244856..2245059	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
KFV37_RS13395	2245468..2245725	+	258	WP_002438963.1	hypothetical protein	Antitoxin
KFV37_RS10985 (KFV37_11025)	2245750..2245938	+	189	WP_001829569.1	hypothetical protein	Toxin
KFV37_RS10990 (KFV37_11030)	2246128..2246682	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
KFV37_RS10995 (KFV37_11035)	2246742..2246975	-	234	WP_001829664.1	hypothetical protein	-
KFV37_RS11000 (KFV37_11040)	2247259..2248005	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
KFV37_RS11005 (KFV37_11045)	2248104..2248388	+	285	WP_001829635.1	hypothetical protein	-
KFV37_RS11010 (KFV37_11050)	2248412..2248636	+	225	WP_001829613.1	hypothetical protein	-
KFV37_RS11015 (KFV37_11055)	2249257..2249457	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2236440..2260724	24284
	-	flank	IS/Tn	-	-	2242315..2242470	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T200445 WP_001829569.1 NZ_CP073876:2245750-2245938 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T200445 NZ_CP097881:1794262-1794516 [Escherichia coli str. K-12 substr. MG1655]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT200445 WP_002438963.1 NZ_CP073876:2245468-2245725 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT200445 NZ_CP097881:1794014-1794265 [Escherichia coli str. K-12 substr. MG1655]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3