Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2248095..2248565 Replicon chromosome
Accession NZ_CP073872
Organism Staphylococcus epidermidis strain B1282731

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV34_RS10995 Protein ID WP_001829569.1
Coordinates 2248377..2248565 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV34_RS13470 Protein ID WP_002438963.1
Coordinates 2248095..2248352 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV34_RS10960 (KFV34_10970) 2243459..2244175 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV34_RS10965 (KFV34_10975) 2244336..2244758 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV34_RS10970 (KFV34_10980) 2244942..2245097 - 156 WP_001829648.1 hypothetical protein -
KFV34_RS10975 (KFV34_10985) 2245683..2246183 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV34_RS10980 (KFV34_10990) 2246454..2247041 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV34_RS10985 (KFV34_10995) 2247255..2247491 + 237 WP_002457224.1 hypothetical protein -
KFV34_RS10990 (KFV34_11000) 2247483..2247686 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV34_RS13470 2248095..2248352 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV34_RS10995 (KFV34_11005) 2248377..2248565 + 189 WP_001829569.1 hypothetical protein Toxin
KFV34_RS11000 (KFV34_11010) 2248755..2249309 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV34_RS11005 (KFV34_11015) 2249369..2249602 - 234 WP_001829664.1 hypothetical protein -
KFV34_RS11010 (KFV34_11020) 2249886..2250632 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV34_RS11015 (KFV34_11025) 2250731..2251015 + 285 WP_001829635.1 hypothetical protein -
KFV34_RS11020 (KFV34_11030) 2251039..2251263 + 225 WP_001829613.1 hypothetical protein -
KFV34_RS11025 (KFV34_11035) 2251884..2252084 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2239067..2266777 27710
- flank IS/Tn - - 2244942..2245097 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200440 WP_001829569.1 NZ_CP073872:2248377-2248565 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200440 NZ_CP097881:842906-843313 [Escherichia coli str. K-12 substr. MG1655]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200440 WP_002438963.1 NZ_CP073872:2248095-2248352 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200440 NZ_CP097881:842659-842925 [Escherichia coli str. K-12 substr. MG1655]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References