Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2248095..2248565 | Replicon | chromosome |
| Accession | NZ_CP073872 | ||
| Organism | Staphylococcus epidermidis strain B1282731 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV34_RS10995 | Protein ID | WP_001829569.1 |
| Coordinates | 2248377..2248565 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV34_RS13470 | Protein ID | WP_002438963.1 |
| Coordinates | 2248095..2248352 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV34_RS10960 (KFV34_10970) | 2243459..2244175 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| KFV34_RS10965 (KFV34_10975) | 2244336..2244758 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV34_RS10970 (KFV34_10980) | 2244942..2245097 | - | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV34_RS10975 (KFV34_10985) | 2245683..2246183 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV34_RS10980 (KFV34_10990) | 2246454..2247041 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV34_RS10985 (KFV34_10995) | 2247255..2247491 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV34_RS10990 (KFV34_11000) | 2247483..2247686 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV34_RS13470 | 2248095..2248352 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV34_RS10995 (KFV34_11005) | 2248377..2248565 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV34_RS11000 (KFV34_11010) | 2248755..2249309 | + | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV34_RS11005 (KFV34_11015) | 2249369..2249602 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV34_RS11010 (KFV34_11020) | 2249886..2250632 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV34_RS11015 (KFV34_11025) | 2250731..2251015 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV34_RS11020 (KFV34_11030) | 2251039..2251263 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV34_RS11025 (KFV34_11035) | 2251884..2252084 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2239067..2266777 | 27710 | |
| - | flank | IS/Tn | - | - | 2244942..2245097 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200440 WP_001829569.1 NZ_CP073872:2248377-2248565 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200440 NZ_CP097881:842906-843313 [Escherichia coli str. K-12 substr. MG1655]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200440 WP_002438963.1 NZ_CP073872:2248095-2248352 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200440 NZ_CP097881:842659-842925 [Escherichia coli str. K-12 substr. MG1655]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |