Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2033569..2034078 Replicon chromosome
Accession NZ_CP073872
Organism Staphylococcus epidermidis strain B1282731

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV34_RS09815 Protein ID WP_001829980.1
Coordinates 2033569..2033778 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV34_RS09820 Protein ID WP_001829893.1
Coordinates 2033785..2034078 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV34_RS09795 (KFV34_09805) 2029147..2030502 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV34_RS09800 (KFV34_09810) 2030514..2031587 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV34_RS09805 (KFV34_09815) 2031978..2033189 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV34_RS09810 (KFV34_09820) 2033289..2033426 - 138 WP_001829949.1 Lmo0850 family protein -
KFV34_RS09815 (KFV34_09825) 2033569..2033778 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV34_RS09820 (KFV34_09830) 2033785..2034078 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV34_RS09825 (KFV34_09835) 2034252..2035736 + 1485 WP_002457116.1 cardiolipin synthase -
KFV34_RS09830 (KFV34_09840) 2035918..2036571 + 654 WP_001829983.1 HD domain-containing protein -
KFV34_RS09835 (KFV34_09845) 2036677..2037549 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV34_RS09840 (KFV34_09850) 2037638..2038276 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV34_RS09845 (KFV34_09855) 2038282..2039070 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200439 WP_001829980.1 NZ_CP073872:c2033778-2033569 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200439 NZ_CP097881:715185-715481 [Escherichia coli str. K-12 substr. MG1655]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200439 WP_001829893.1 NZ_CP073872:c2034078-2033785 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200439 NZ_CP097881:715483-715878 [Escherichia coli str. K-12 substr. MG1655]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References