Detailed information of TA system TA200435

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2247936..2248406
• Replicon: chromosome
• Accession: NZ_CP073869
• Organism: Staphylococcus epidermidis strain B1279591

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: KFV51_RS10990
• Protein ID: WP_001829569.1
• Coordinates: 2248218..2248406 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: KFV51_RS13430
• Protein ID: WP_002438963.1
• Coordinates: 2247936..2248193 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFV51_RS10955 (KFV51_10995)	2243300..2244016	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
KFV51_RS10960 (KFV51_11000)	2244177..2244599	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
KFV51_RS10965 (KFV51_11005)	2244783..2244938	-	156	WP_001829648.1	hypothetical protein	-
KFV51_RS10970 (KFV51_11010)	2245524..2246024	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
KFV51_RS10975 (KFV51_11015)	2246295..2246882	-	588	WP_001829615.1	histidine phosphatase family protein	-
KFV51_RS10980 (KFV51_11020)	2247096..2247332	+	237	WP_002457224.1	hypothetical protein	-
KFV51_RS10985 (KFV51_11025)	2247324..2247527	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
KFV51_RS13430	2247936..2248193	+	258	WP_002438963.1	hypothetical protein	Antitoxin
KFV51_RS10990 (KFV51_11030)	2248218..2248406	+	189	WP_001829569.1	hypothetical protein	Toxin
KFV51_RS10995 (KFV51_11035)	2248596..2249150	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
KFV51_RS11000 (KFV51_11040)	2249210..2249443	-	234	WP_001829664.1	hypothetical protein	-
KFV51_RS11005 (KFV51_11045)	2249727..2250473	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
KFV51_RS11010 (KFV51_11050)	2250572..2250856	+	285	WP_001829635.1	hypothetical protein	-
KFV51_RS11015 (KFV51_11055)	2250880..2251104	+	225	WP_001829613.1	hypothetical protein	-
KFV51_RS11020 (KFV51_11060)	2251725..2251925	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2244783..2244938	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T200435 WP_001829569.1 NZ_CP073869:2248218-2248406 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T200435 NZ_CP097873:1425553-1425840 [Vibrio parahaemolyticus]
ATGAAAGTAGTTTGGTCTCCATTAGCGCTTCAAAAGTTAGGCGATGCAGCGGAGTTCATTTCTTTGGATAATCCATCTGC
GGCAGAAAAGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAGATGGGGCGCTTTGTTCCTG
AAATGCCTCATACGAATTATCGTGAAATTATTTTTGGTCACTATCGTATTATCTACAGCTTAAGTCATGAAATCCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATGTTGTCGGAAGATGATGTGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT200435 WP_002438963.1 NZ_CP073869:2247936-2248193 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT200435 NZ_CP097873:1425275-1425556 [Vibrio parahaemolyticus]
ATGAGTCGTATTCATTTCGATCAAGACATTCAGCCGTTGTCTGAGTTTCGCGCAGGTGTAGCTTCTTACATCAAACAAAT
CAATGAGACTCGCCGTCCATTGGTAATTACTCAACGTGGCAAAGGTGTTGCTGTTGTCCTTGACGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGGACAGCGGAAGCTCAATTAGCTTCAGGTCTTGGCGTTTCCAAT
GATGATGCGCGTGCTCAAGTTTTGGGGCGCATTAAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3