Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2033409..2033918 Replicon chromosome
Accession NZ_CP073869
Organism Staphylococcus epidermidis strain B1279591

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV51_RS09810 Protein ID WP_001829980.1
Coordinates 2033409..2033618 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV51_RS09815 Protein ID WP_001829893.1
Coordinates 2033625..2033918 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV51_RS09790 (KFV51_09830) 2028987..2030342 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV51_RS09795 (KFV51_09835) 2030354..2031427 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV51_RS09800 (KFV51_09840) 2031818..2033029 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV51_RS09805 (KFV51_09845) 2033129..2033266 - 138 WP_001829949.1 Lmo0850 family protein -
KFV51_RS09810 (KFV51_09850) 2033409..2033618 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV51_RS09815 (KFV51_09855) 2033625..2033918 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV51_RS09820 (KFV51_09860) 2034092..2035576 + 1485 WP_002457116.1 cardiolipin synthase -
KFV51_RS09825 (KFV51_09865) 2035758..2036411 + 654 WP_001829983.1 HD domain-containing protein -
KFV51_RS09830 (KFV51_09870) 2036517..2037389 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV51_RS09835 (KFV51_09875) 2037478..2038116 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV51_RS09840 (KFV51_09880) 2038122..2038910 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200434 WP_001829980.1 NZ_CP073869:c2033618-2033409 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200434 NZ_CP097873:c1351572-1351294 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAGGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200434 WP_001829893.1 NZ_CP073869:c2033918-2033625 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200434 NZ_CP097873:c1351853-1351569 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGCGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCATGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTAAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References