Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 1069540..1070165 Replicon chromosome
Accession NZ_CP073865
Organism Staphylococcus epidermidis strain B1276912

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag KFV35_RS05285 Protein ID WP_002504557.1
Coordinates 1069770..1070165 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag KFV35_RS05280 Protein ID WP_002504558.1
Coordinates 1069540..1069770 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV35_RS05215 (KFV35_05255) 1064609..1065091 + 483 WP_002504570.1 hypothetical protein -
KFV35_RS05220 (KFV35_05260) 1065107..1065286 + 180 WP_002504569.1 hypothetical protein -
KFV35_RS05225 (KFV35_05265) 1065271..1065456 + 186 WP_001187008.1 hypothetical protein -
KFV35_RS05230 (KFV35_05270) 1065472..1065756 + 285 WP_002504568.1 hypothetical protein -
KFV35_RS05235 (KFV35_05275) 1065753..1065908 + 156 WP_002504567.1 transcriptional activator RinB -
KFV35_RS05240 (KFV35_05280) 1065934..1066206 + 273 WP_002504566.1 hypothetical protein -
KFV35_RS05245 (KFV35_05285) 1066222..1066764 + 543 WP_002504565.1 hypothetical protein -
KFV35_RS05250 (KFV35_05290) 1066757..1066933 + 177 WP_002504564.1 hypothetical protein -
KFV35_RS05255 (KFV35_05295) 1066953..1067174 + 222 WP_002504563.1 hypothetical protein -
KFV35_RS05260 (KFV35_05300) 1067174..1067899 + 726 WP_010959229.1 metallophosphoesterase -
KFV35_RS05265 (KFV35_05305) 1067892..1068209 + 318 WP_002504561.1 hypothetical protein -
KFV35_RS05270 (KFV35_05310) 1068209..1068859 + 651 WP_002504560.1 hypothetical protein -
KFV35_RS05275 (KFV35_05315) 1068859..1069377 + 519 WP_002504559.1 metallophosphoesterase -
KFV35_RS05280 (KFV35_05320) 1069540..1069770 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
KFV35_RS05285 (KFV35_05325) 1069770..1070165 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KFV35_RS05290 (KFV35_05330) 1070468..1070659 + 192 WP_002504556.1 hypothetical protein -
KFV35_RS05295 (KFV35_05335) 1070643..1070912 + 270 WP_000755772.1 hypothetical protein -
KFV35_RS05300 (KFV35_05340) 1070969..1071463 + 495 WP_010959224.1 hypothetical protein -
KFV35_RS05305 (KFV35_05345) 1071467..1072267 + 801 WP_000686449.1 metallophosphoesterase -
KFV35_RS05310 (KFV35_05350) 1072376..1073098 + 723 WP_002504538.1 hypothetical protein -
KFV35_RS05315 (KFV35_05355) 1073204..1073845 + 642 WP_002504537.1 hypothetical protein -
KFV35_RS13765 1073876..1074010 - 135 WP_002504536.1 hypothetical protein -
KFV35_RS05320 (KFV35_05360) 1074093..1074497 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T200429 WP_002504557.1 NZ_CP073865:1069770-1070165 [Staphylococcus epidermidis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T200429 NZ_CP097870:3614058-3614291 [Thauera sp. GDN1]
ATGCAGGAAGCGAAGGCGCGCATGTCGGAGTTGGTCAAGCGCGCCCAGACCCAGCCCCAGGACATCACCCTGCACGGCAA
GTCGGTCGCAGTGGTGATCTCGCGCGAAACTTTTGATCGGTTGTCACAGGCGCAGGACTCGCTGGTGGACTTCATGCGAC
GCTCACCCTTGTTCGGAACAGACGACATAGCCCTCGAACGCGAGCAGAGCCTGACGCGCGAGGTCTTGTTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT200429 WP_002504558.1 NZ_CP073865:1069540-1069770 [Staphylococcus epidermidis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT200429 NZ_CP097870:3614288-3614701 [Thauera sp. GDN1]
TTGAGCTACCTGATCGACACCAACGTGTTGTCCGAACTGCGGCGCAAGTCTCCAGACCCCGGCGTGGTCGCCTGGTTTTC
GCAGCGGCCGCCCACCACCCTGCATCTCTCTGTGCTGACGCTCGGCGAGATTCGCAAGGGCATTGAAGGCGTGGGTGACG
AAGTTCGAAAGCAGACGCTGATCGATTGGCTCGAAACGGATCTCCCCACCTTCTTCACCGGGCGCATCCTCGACGTCAAT
GGCGCAGTGGCCGATCGCTGGGGGCGTCTGGTCGCTGCAGCCGGACGACCGCTGCCCACGATCGACAGCCTGCTCGCAGC
GACCGCCCTGGAACACGATCTGGTACTGGTGACACGCAACACCAAGGATTTCGCCGGTCTGCCCGTCGAGGTCTTCAACC
CCTGGACGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References