Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 929160..929669 Replicon chromosome
Accession NZ_CP073865
Organism Staphylococcus epidermidis strain B1276912

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV35_RS04575 Protein ID WP_001829980.1
Coordinates 929460..929669 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV35_RS04570 Protein ID WP_001829893.1
Coordinates 929160..929453 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV35_RS04545 (KFV35_04585) 924168..924956 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV35_RS04550 (KFV35_04590) 924962..925600 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV35_RS04555 (KFV35_04595) 925689..926561 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV35_RS04560 (KFV35_04600) 926667..927320 - 654 WP_001829983.1 HD domain-containing protein -
KFV35_RS04565 (KFV35_04605) 927502..928986 - 1485 WP_002457116.1 cardiolipin synthase -
KFV35_RS04570 (KFV35_04610) 929160..929453 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV35_RS04575 (KFV35_04615) 929460..929669 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV35_RS04580 (KFV35_04620) 929812..929949 + 138 WP_001829949.1 Lmo0850 family protein -
KFV35_RS04585 (KFV35_04625) 930049..931260 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV35_RS04590 (KFV35_04630) 931651..932724 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV35_RS04595 (KFV35_04635) 932736..934091 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200427 WP_001829980.1 NZ_CP073865:929460-929669 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200427 NZ_CP097870:2510229-2511524 [Thauera sp. GDN1]
ATGACGCATGAGCTGGAGGTCTGGCTCTTCTCCGAGCACGTCGGCACCCTGGCGCTGGTCGATGGGCGCCTCGGCTTTTG
CTACGCCCCCGGCTGGCTGTCGCGGCCGAACGCAGTGGCCCTGTCGCACTCGCTGCCCTTGCGGGCCCAGCCGTTCGACG
ATCGCGCGACGCGCCCCTTCTTTGCCGGCCTGCTGCCGGAAGGACAGATGCGTCGCCTGATTGCGCGGCAATTCCAGGTC
TCGGGCCAGAACGACTTCGCCCTGCTCGACCACATCGGCGGCGAATGCGCCGGAGCGGTTACATTCCTCGCGCCCGGGCA
GAGTCTGCCGACGCCTGCGCAGACCGGCGCGGTTAGATGGCTGAGTGACGACGAAGTCGTTGCCGTACTGGACGAACTGC
CTCGTCGCCCCATGCTGGCAGGCAAGGACGGTTTGCGGCTCTCTCTCGCGGGTGCCCAAGACAAGCTGCCGGTCGTGTTC
GATGGCACACGCCTCGGCTTGCCACTCAACGGCACGCCGAGCTCCCACATCCTCAAGCCGCCGGTCCACGGCGTCGAGGA
CAGCGTGATCAACGAAGGATTCTGCATGGCATTGGCAGAGGCGCTGCAGCTCGAGCCGGCGAAGGCGAGCATCTATGCCG
TATTGAATCGCCCCTTCCTGCTGGTCGACCGCTACGACCGTGTGCTGGATGCAAAGGGGTGCCGCCAGCGCCTCCACCAG
GAAGACTTCTGCCAGGCACTCGGTGTGGTGCCCGAGATGAAGTATCAGAACGAGGGCGGGCCGGATCTTGCGCAATGCTT
CGATCTGGTGCGCCGTGCGACGCGCCCGAGCGCGCCCCAGGTGCTGCGTCTGTTCGATTACGTAATTTTCAACGCGCTCA
TCGGCAATCACGATGCGCACGCCAAGAACTTTTCCCTGCTCTACGCCGGCAGGACGCCGATTCTCGCCCCGCTCTACGAC
ACGCTCTCGACCGCCGTCTATCCGACCCTGACGCCGAAGATGGCGATGAAGATCGGCAGCAAGTACAAGTTCAGCGAAGT
CGAGGCCCGGCACTGGGAGCAATTGGCCGAGGGCGCGGGTCTTGCCAAGGCGCCGGCGCGGCGGCGCATCCTGGAACTGG
CGAACTCACTGCCCCGCGCCGCACGCGCGCTCCAGTCCGACCGCGCGCGTGGTTTTGCCGGGAACGGCGTCGTTGAAAGC
ATCGTCGCCTTGATCGAACAACGCTGCGCGCTGACGCTTCGCAGGCTGAGCGCTCCCGCCTCCCGCGATGAAGAAGGCTT
CGCCTCGCCGCAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200427 WP_001829893.1 NZ_CP073865:929160-929453 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200427 NZ_CP097870:2509979-2510239 [Thauera sp. GDN1]
ATGACATCCATTAGCTCCGCCCAACAACTCGGCGACGCCCTGCGTGCTGCCCGCAAGCAGCTCGGCCTGACCCAGCCTCA
ACTGGCGCTGGCCGCGGGCGTGGGCGTGCGTTTCATCGTCGACCTCGAAGCGGGCAAGCCGACCGTGCGGCTTGAGAACG
TCCTGCGGGTGATCGATGCATTGGGGGGAGAGCTCCAGCTGAGCGGTCTGCCCACAGCGGAAGCCGATCACGCCACCGAG
GGCAGCGGCCATGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References