Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 714673..715143 | Replicon | chromosome |
| Accession | NZ_CP073865 | ||
| Organism | Staphylococcus epidermidis strain B1276912 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KFV35_RS03395 | Protein ID | WP_001829569.1 |
| Coordinates | 714673..714861 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KFV35_RS13745 | Protein ID | WP_002438963.1 |
| Coordinates | 714886..715143 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV35_RS03365 (KFV35_03405) | 711154..711354 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| KFV35_RS03370 (KFV35_03410) | 711975..712199 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| KFV35_RS03375 (KFV35_03415) | 712223..712507 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| KFV35_RS03380 (KFV35_03420) | 712606..713352 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KFV35_RS03385 (KFV35_03425) | 713636..713869 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| KFV35_RS03390 (KFV35_03430) | 713929..714483 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KFV35_RS03395 (KFV35_03435) | 714673..714861 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KFV35_RS13745 | 714886..715143 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KFV35_RS03400 (KFV35_03440) | 715552..715755 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KFV35_RS03405 (KFV35_03445) | 715747..715983 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| KFV35_RS03410 (KFV35_03450) | 716197..716784 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KFV35_RS03415 (KFV35_03455) | 717055..717555 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KFV35_RS03420 (KFV35_03460) | 718141..718296 | + | 156 | WP_001829648.1 | hypothetical protein | - |
| KFV35_RS03425 (KFV35_03465) | 718480..718902 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KFV35_RS03430 (KFV35_03470) | 719063..719779 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | clpP | 682919..724171 | 41252 | |
| - | flank | IS/Tn | - | - | 718141..718296 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200426 WP_001829569.1 NZ_CP073865:c714861-714673 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200426 NZ_CP097870:1342308-1342808 [Thauera sp. GDN1]
ATGAGCTTGCGCGGTCCAGAATCTCTTGGCTTGCAGCATCGGCTGGAGGGATTCGATTGCGGCAAGCCTGCCCTGAACGA
CTGGCTGCTGTGCCACGCGAGACAAGCTCAGGGCAGCGGATCGGCCAAGACCTTCGTGGTGGCCGATGATGACCGGGTGG
CAGGCTACTTCAGTCTGACCGTTGGTCAGATCGACACGCTGGAGGCGCCGGAGCGCATCCGCAAGGGGATGGGGCAGTAT
CCTTTGCCGGTGGTGATTCTGGCGCGGCTGGCAGTATCAAAGCAGGATCGGGGGCGCGGCATAGGCTTCGGCCTGCTGCA
GGATGCGATTCGGCGCACGATGCTGATTGCCGAGCAGGCTGGCATCCGGGCCATGCTGACCCATCCGATCGATGAGGAGG
CGGCGAAGTTCTACACCCGCTTCGGCTTCATCGCCTCGCCGCTGCGCGAGCAGCAGCTGCTACTGCTGCTCAAGGATGCG
AGGAAGTTCGTGATGGCCTGA
ATGAGCTTGCGCGGTCCAGAATCTCTTGGCTTGCAGCATCGGCTGGAGGGATTCGATTGCGGCAAGCCTGCCCTGAACGA
CTGGCTGCTGTGCCACGCGAGACAAGCTCAGGGCAGCGGATCGGCCAAGACCTTCGTGGTGGCCGATGATGACCGGGTGG
CAGGCTACTTCAGTCTGACCGTTGGTCAGATCGACACGCTGGAGGCGCCGGAGCGCATCCGCAAGGGGATGGGGCAGTAT
CCTTTGCCGGTGGTGATTCTGGCGCGGCTGGCAGTATCAAAGCAGGATCGGGGGCGCGGCATAGGCTTCGGCCTGCTGCA
GGATGCGATTCGGCGCACGATGCTGATTGCCGAGCAGGCTGGCATCCGGGCCATGCTGACCCATCCGATCGATGAGGAGG
CGGCGAAGTTCTACACCCGCTTCGGCTTCATCGCCTCGCCGCTGCGCGAGCAGCAGCTGCTACTGCTGCTCAAGGATGCG
AGGAAGTTCGTGATGGCCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200426 WP_002438963.1 NZ_CP073865:c715143-714886 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200426 NZ_CP097870:1342018-1342311 [Thauera sp. GDN1]
ATGGTTGCCGTTGCATCTTCTCCCGCTGCCCGTTCCGCCCGCCTGGGCCTGCGCGCCACGCCTGAACAGGAAGTCGTGCT
GCGCCGTGCTGCCGAAGTGGCGCACAAATCCCTGACCGATTTCATTCTGGATAGCGCCTGCCTGGCCGCCGAGCAGACCT
TGCTCGACCAGCGCCTGTTCATGGTGACTGGCAGCCAGTATCAAGCCCTGATGGATTTGCTGGATCAGCCAGAGCAGCCC
AACGAGGGTCTGCGCGATCTGTTCTCGCGCAAAGCCCCCTGGGACCAGGCATGA
ATGGTTGCCGTTGCATCTTCTCCCGCTGCCCGTTCCGCCCGCCTGGGCCTGCGCGCCACGCCTGAACAGGAAGTCGTGCT
GCGCCGTGCTGCCGAAGTGGCGCACAAATCCCTGACCGATTTCATTCTGGATAGCGCCTGCCTGGCCGCCGAGCAGACCT
TGCTCGACCAGCGCCTGTTCATGGTGACTGGCAGCCAGTATCAAGCCCTGATGGATTTGCTGGATCAGCCAGAGCAGCCC
AACGAGGGTCTGCGCGATCTGTTCTCGCGCAAAGCCCCCTGGGACCAGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |