200425

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2248076..2248546 Replicon chromosome
Accession NZ_CP073863
Organism Staphylococcus epidermidis strain B1276296

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV46_RS10910 Protein ID WP_001829569.1
Coordinates 2248358..2248546 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV46_RS13380 Protein ID WP_002438963.1
Coordinates 2248076..2248333 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV46_RS10875 (KFV46_10885) 2243440..2244156 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV46_RS10880 (KFV46_10890) 2244317..2244739 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV46_RS10885 (KFV46_10895) 2244923..2245078 - 156 WP_001829648.1 hypothetical protein -
KFV46_RS10890 (KFV46_10900) 2245664..2246164 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV46_RS10895 (KFV46_10905) 2246435..2247022 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV46_RS10900 (KFV46_10910) 2247236..2247472 + 237 WP_002457224.1 hypothetical protein -
KFV46_RS10905 (KFV46_10915) 2247464..2247667 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV46_RS13380 2248076..2248333 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV46_RS10910 (KFV46_10920) 2248358..2248546 + 189 WP_001829569.1 hypothetical protein Toxin
KFV46_RS10915 (KFV46_10925) 2248736..2249290 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV46_RS10920 (KFV46_10930) 2249350..2249583 - 234 WP_001829664.1 hypothetical protein -
KFV46_RS10925 (KFV46_10935) 2249867..2250613 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV46_RS10930 (KFV46_10940) 2250712..2250996 + 285 WP_001829635.1 hypothetical protein -
KFV46_RS10935 (KFV46_10945) 2251020..2251244 + 225 WP_001829613.1 hypothetical protein -
KFV46_RS10940 (KFV46_10950) 2251865..2252065 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2239048..2266758 27710
- flank IS/Tn - - 2244923..2245078 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(11-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200425 WP_001829569.1 NZ_CP073863:2248358-2248546 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200425 NZ_CP097870:c764318-763899 [Thauera sp. GDN1]
GTGATCTACCTGCTCGACACGAATATCCTGATCTACCTGATCAAGAGCCAGCCGCCCGGCATCGCGCAGCGCATCGACGC
ACTCCCTGAGAGCGACACCCTGTGCATGTCTTTCGTGACCTGGGCAGAGCTGCTGAAGGGTGCCGAGCGCAGCACCCGCA
AGACGGAGGTGCTGCGGCGGCTGAACGCCCTGGCACGCCAGGTACCGGTGCGCTACCCCGCCGACCCCGCCATCTGCCGG
CATTACGCGGAACAGGCCACCCGCCTGAAAGAGGCAGGCACGCCGATCGGCGCGAACGACCTGTGGATCGCCTGCCATGC
GCTGGCCGAAGACGCCACCCTGGTCACCCACAACACGCGCGAGTTCAGGCGCATTGCGGGTTTGTGCGTCGAGGACTGGG
TGTCCGCCGAAAAAGACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200425 WP_002438963.1 NZ_CP073863:2248076-2248333 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200425 NZ_CP097870:c764578-764315 [Thauera sp. GDN1]
ATGGAAACACTGCCCAGCCGTGTCTTCAACAACGGTAACAGCCAGGCGGTCCGTATCCCGGCAGAGTTCCGCCTCGACAC
CGACCGCGTCAGCATCACGCGCAACGACGCGGGCGATCTGGTGATCCACCCCTTGCGAGTGCAACGCGGCACGGCCCTGA
TGCAGGCCCTGAAAGCGCTGCGCGAAGTGGACGACGCCTTCGTCGCCGCGCTCGAGTCCGAGCAGGAAGCGCCGCTTCCG
GTGCAGGAGCGCGAGGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References