Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2031050..2031559 Replicon chromosome
Accession NZ_CP073862
Organism Staphylococcus epidermidis strain B1276219

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV45_RS09830 Protein ID WP_001829980.1
Coordinates 2031050..2031259 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV45_RS09835 Protein ID WP_001829893.1
Coordinates 2031266..2031559 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV45_RS09810 (KFV45_09820) 2026628..2027983 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV45_RS09815 (KFV45_09825) 2027995..2029068 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV45_RS09820 (KFV45_09830) 2029459..2030670 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV45_RS09825 (KFV45_09835) 2030770..2030907 - 138 WP_001829949.1 Lmo0850 family protein -
KFV45_RS09830 (KFV45_09840) 2031050..2031259 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV45_RS09835 (KFV45_09845) 2031266..2031559 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV45_RS09840 (KFV45_09850) 2031733..2033217 + 1485 WP_002457116.1 cardiolipin synthase -
KFV45_RS09845 (KFV45_09855) 2033399..2034052 + 654 WP_001829983.1 HD domain-containing protein -
KFV45_RS09850 (KFV45_09860) 2034158..2035030 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV45_RS09855 (KFV45_09865) 2035119..2035757 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV45_RS09860 (KFV45_09870) 2035763..2036551 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200419 WP_001829980.1 NZ_CP073862:c2031259-2031050 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200419 NZ_CP097857:c5548793-5548512 [Pseudomonas sp. B111]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200419 WP_001829893.1 NZ_CP073862:c2031559-2031266 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200419 NZ_CP097857:c5549017-5548790 [Pseudomonas sp. B111]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References