Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2248093..2248563 Replicon chromosome
Accession NZ_CP073859
Organism Staphylococcus epidermidis strain B1275857

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV44_RS10950 Protein ID WP_001829569.1
Coordinates 2248375..2248563 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV44_RS13435 Protein ID WP_002438963.1
Coordinates 2248093..2248350 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV44_RS10915 (KFV44_10925) 2243457..2244173 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV44_RS10920 (KFV44_10930) 2244334..2244756 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV44_RS10925 (KFV44_10935) 2244940..2245077 - 138 WP_162161215.1 hypothetical protein -
KFV44_RS10930 (KFV44_10940) 2245681..2246181 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV44_RS10935 (KFV44_10945) 2246452..2247039 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV44_RS10940 (KFV44_10950) 2247253..2247489 + 237 WP_002457224.1 hypothetical protein -
KFV44_RS10945 (KFV44_10955) 2247481..2247684 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV44_RS13435 2248093..2248350 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV44_RS10950 (KFV44_10960) 2248375..2248563 + 189 WP_001829569.1 hypothetical protein Toxin
KFV44_RS10955 (KFV44_10965) 2248753..2249307 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV44_RS10960 (KFV44_10970) 2249367..2249600 - 234 WP_001829664.1 hypothetical protein -
KFV44_RS10965 (KFV44_10975) 2249884..2250630 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV44_RS10970 (KFV44_10980) 2250729..2251013 + 285 WP_001829635.1 hypothetical protein -
KFV44_RS10975 (KFV44_10985) 2251037..2251261 + 225 WP_001829613.1 hypothetical protein -
KFV44_RS10980 (KFV44_10990) 2251882..2252082 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2239065..2266775 27710
- flank IS/Tn - - 2244940..2245095 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200415 WP_001829569.1 NZ_CP073859:2248375-2248563 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200415 NZ_CP097857:855282-856151 [Pseudomonas sp. B111]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200415 WP_002438963.1 NZ_CP073859:2248093-2248350 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200415 NZ_CP097857:856144-856977 [Pseudomonas sp. B111]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCATCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References