Detailed information of TA system TA200410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2252849..2253319
• Replicon: chromosome
• Accession: NZ_CP073857
• Organism: Staphylococcus epidermidis strain B1272014

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: KFV47_RS10950
• Protein ID: WP_001829569.1
• Coordinates: 2253131..2253319 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: KFV47_RS14040
• Protein ID: WP_002438963.1
• Coordinates: 2252849..2253106 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFV47_RS10915 (KFV47_10925)	2248213..2248929	-	717	WP_001831974.1	type I 3-dehydroquinate dehydratase	-
KFV47_RS10920 (KFV47_10930)	2249090..2249512	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
KFV47_RS10925 (KFV47_10935)	2249696..2249851	-	156	WP_001829648.1	hypothetical protein	-
KFV47_RS10930 (KFV47_10940)	2250437..2250937	+	501	WP_001829623.1	GNAT family N-acetyltransferase	-
KFV47_RS10935 (KFV47_10945)	2251208..2251795	-	588	WP_001829615.1	histidine phosphatase family protein	-
KFV47_RS10940 (KFV47_10950)	2252009..2252245	+	237	WP_002457224.1	hypothetical protein	-
KFV47_RS10945 (KFV47_10955)	2252237..2252440	-	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
KFV47_RS14040	2252849..2253106	+	258	WP_002438963.1	hypothetical protein	Antitoxin
KFV47_RS10950 (KFV47_10960)	2253131..2253319	+	189	WP_001829569.1	hypothetical protein	Toxin
KFV47_RS10955 (KFV47_10965)	2253509..2254063	+	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
KFV47_RS10960 (KFV47_10970)	2254123..2254356	-	234	WP_001829664.1	hypothetical protein	-
KFV47_RS10965 (KFV47_10975)	2254640..2255386	+	747	WP_002438959.1	poly-gamma-glutamate hydrolase family protein	-
KFV47_RS10970 (KFV47_10980)	2255485..2255769	+	285	WP_001829635.1	hypothetical protein	-
KFV47_RS10975 (KFV47_10985)	2255793..2256017	+	225	WP_001829613.1	hypothetical protein	-
KFV47_RS10980 (KFV47_10990)	2256638..2256838	-	201	WP_001829681.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2249696..2249851	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T200410 WP_001829569.1 NZ_CP073857:2253131-2253319 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T200410 NZ_CP097843:c1548984-1548730 [Streptococcus oralis]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCGGATTATTGCTATTGGCAAAACCAAGATAAGAAAACATTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCTTTTGTAGGAATGGGGAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGGTCGCGGCGCATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGGGATAACATCGCTTTCTTGTCCTTT
AAGGATCATTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT200410 WP_002438963.1 NZ_CP073857:2252849-2253106 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT200410 NZ_CP097843:c1549242-1548988 [Streptococcus oralis]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGACTACATGAAAAAAGTAAACGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGATATTGTAGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAGGAAACCCTGA
GAATCGCTCAAAATAAGGAACTTTCTGACAAGGTCTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGCACTCAGGTGCAT
GTGATTGAGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3