Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2038323..2038832 Replicon chromosome
Accession NZ_CP073857
Organism Staphylococcus epidermidis strain B1272014

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV47_RS09770 Protein ID WP_001829980.1
Coordinates 2038323..2038532 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV47_RS09775 Protein ID WP_001829893.1
Coordinates 2038539..2038832 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV47_RS09750 (KFV47_09760) 2033901..2035256 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV47_RS09755 (KFV47_09765) 2035268..2036341 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV47_RS09760 (KFV47_09770) 2036732..2037943 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV47_RS09765 (KFV47_09775) 2038043..2038180 - 138 WP_001829949.1 Lmo0850 family protein -
KFV47_RS09770 (KFV47_09780) 2038323..2038532 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV47_RS09775 (KFV47_09785) 2038539..2038832 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV47_RS09780 (KFV47_09790) 2039006..2040490 + 1485 WP_002457116.1 cardiolipin synthase -
KFV47_RS09785 (KFV47_09795) 2040672..2041325 + 654 WP_001829983.1 HD domain-containing protein -
KFV47_RS09790 (KFV47_09800) 2041431..2042303 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV47_RS09795 (KFV47_09805) 2042392..2043030 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV47_RS09800 (KFV47_09810) 2043036..2043824 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200409 WP_001829980.1 NZ_CP073857:c2038532-2038323 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200409 NZ_CP097843:c1520177-1519812 [Streptococcus oralis]
ATGCATACGATTTACTTCTATAAGGACAAAAATGGAAACGAGCCAGTCTTAGATTACATGAGAGAATTGGCTAGAAAGAA
GAGTAAGGATAGTCGCATCAAACTCAATAAACTAAATGACTATATCGAGTTGCTTAGTCATCATGGGACTAGAACTGGTG
AACCCTATATCAAACATTTAGAAGATGAGATTTGGGAACTAAGACCTCTTAGAGATAGGATTTTATTTGTAGCGTGGCTT
GATGGGAGTTTTGTTCTCTTACATCATTTTGTCAAAAAGACTCAGAAAACTCCTAGGAGAGAAATTGATAAAGCCAAGCG
TGAACTGAAGGACTTAAAAGAAAGAGGGTTAAGTGATGAAGAATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200409 WP_001829893.1 NZ_CP073857:c2038832-2038539 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200409 NZ_CP097843:c1519822-1519529 [Streptococcus oralis]
ATGAAGAATAGTGCCATTGGAAGTAATTGGAAGGATGTTCGGTCAGAACTTTTTACCAAGGAGGAAATACTTGAAAGTGA
TATGCGAGTAGCTATCATGAGTGAGTTGATTGAGGCCAGACGAGATCAAGGAATCAGTCAGAAAAAGCTAGAGGAACTCA
GTGGAGTAAGTCAGCCCGTCATAGCTAGGATGGAAACAGGCAAGACTAGCCCTCAATTGGATACGGTTTTGAAAGTTTTA
GCCAGTTTAGGCAAGACACTAGCAGTCGTCCCACTTGAACAGGAAAAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References