200404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2031147..2031656 Replicon chromosome
Accession NZ_CP073855
Organism Staphylococcus epidermidis strain B1269488

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV48_RS09805 Protein ID WP_001829980.1
Coordinates 2031147..2031356 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV48_RS09810 Protein ID WP_001829893.1
Coordinates 2031363..2031656 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV48_RS09785 (KFV48_09805) 2026725..2028080 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV48_RS09790 (KFV48_09810) 2028092..2029165 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV48_RS09795 (KFV48_09815) 2029556..2030767 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV48_RS09800 (KFV48_09820) 2030867..2031004 - 138 WP_001829949.1 Lmo0850 family protein -
KFV48_RS09805 (KFV48_09825) 2031147..2031356 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV48_RS09810 (KFV48_09830) 2031363..2031656 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV48_RS09815 (KFV48_09835) 2031830..2033314 + 1485 WP_002457116.1 cardiolipin synthase -
KFV48_RS09820 (KFV48_09840) 2033496..2034149 + 654 WP_001829983.1 HD domain-containing protein -
KFV48_RS09825 (KFV48_09845) 2034255..2035127 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV48_RS09830 (KFV48_09850) 2035216..2035854 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV48_RS09835 (KFV48_09855) 2035860..2036648 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200404 WP_001829980.1 NZ_CP073855:c2031356-2031147 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200404 NZ_CP097841:110466-110741 [Shigella flexneri]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200404 WP_001829893.1 NZ_CP073855:c2031656-2031363 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200404 NZ_CP097841:110182-110466 [Shigella flexneri]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGTCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References