Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2019944..2020473 Replicon chromosome
Accession NZ_CP073855
Organism Staphylococcus epidermidis strain B1269488

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV48_RS09745 Protein ID WP_001829891.1
Coordinates 2019944..2020306 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV48_RS09750 Protein ID WP_001829931.1
Coordinates 2020303..2020473 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV48_RS09725 (KFV48_09745) 2016945..2017715 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
KFV48_RS09730 (KFV48_09750) 2017729..2018169 - 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV48_RS09735 (KFV48_09755) 2018171..2018497 - 327 WP_001829952.1 anti-sigma factor antagonist -
KFV48_RS09740 (KFV48_09760) 2018597..2019598 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV48_RS09745 (KFV48_09765) 2019944..2020306 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV48_RS09750 (KFV48_09770) 2020303..2020473 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV48_RS09755 (KFV48_09775) 2020560..2021708 - 1149 WP_002468951.1 alanine racemase -
KFV48_RS09760 (KFV48_09780) 2021774..2022127 - 354 WP_001829915.1 holo-ACP synthase -
KFV48_RS09765 (KFV48_09785) 2022175..2022684 - 510 WP_001829888.1 PH domain-containing protein -
KFV48_RS09770 (KFV48_09790) 2022671..2024176 - 1506 WP_001829976.1 PH domain-containing protein -
KFV48_RS09775 (KFV48_09795) 2024169..2024648 - 480 WP_063278489.1 PH domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200403 WP_001829891.1 NZ_CP073855:c2020306-2019944 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200403 NZ_CP097841:c22069-21584 [Shigella flexneri]
ATGGGATGTGTAACTGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCAGTGAAGCTGTACTTGA
TGACTGGTTAAAGCAGAAGGAGCTAAAAAATCAGGCAATCGGAGCCACCCGGACTTTTGTTGTATGCAGAAAAGGTACGC
AACAAATAGTCGGTTTTTACTCACTGGCCACTGGTAGTGTCAATCATACAGAAGCTACAGGTAACCTTCGGCGCAATATG
CCAGACCCCATTCCTGTAATTATACTTGCACGCCTGGCTGTAGATGTGTCATTTCGAGGAAAAGGGCTTGGCGCGGATTT
ACTTCATGATGCAGTTCGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAACTCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200403 WP_001829931.1 NZ_CP073855:c2020473-2020303 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200403 NZ_CP097841:c22341-22057 [Shigella flexneri]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGAGCAAGAGAATCACAGCGGATACTCATTGATGC
TGCTGCAGAAATTCTTCATAAGTCGCGTACAGATTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATTGAAATGCTTGATGCTCCGGTTGCAGATGATCCT
GCCATCGAAAAATTGCTGGCAAGGAAACCTCAATGGGATGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0


Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References