200393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 693055..693584 Replicon chromosome
Accession NZ_CP073850
Organism Staphylococcus epidermidis strain B1266911

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV33_RS03595 Protein ID WP_001829891.1
Coordinates 693222..693584 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV33_RS03590 Protein ID WP_001829931.1
Coordinates 693055..693225 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV33_RS03565 (KFV33_03565) 688880..689359 + 480 WP_063278489.1 PH domain-containing protein -
KFV33_RS03570 (KFV33_03570) 689352..690857 + 1506 WP_001829976.1 PH domain-containing protein -
KFV33_RS03575 (KFV33_03575) 690844..691353 + 510 WP_001829888.1 PH domain-containing protein -
KFV33_RS03580 (KFV33_03580) 691401..691754 + 354 WP_001829915.1 holo-ACP synthase -
KFV33_RS03585 (KFV33_03585) 691820..692968 + 1149 WP_002468951.1 alanine racemase -
KFV33_RS03590 (KFV33_03590) 693055..693225 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV33_RS03595 (KFV33_03595) 693222..693584 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV33_RS03600 (KFV33_03600) 693930..694931 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV33_RS03605 (KFV33_03605) 695031..695357 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV33_RS03610 (KFV33_03610) 695359..695799 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV33_RS03615 (KFV33_03615) 695813..696583 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200393 WP_001829891.1 NZ_CP073850:693222-693584 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200393 NZ_CP097840:1796867-1797274 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200393 WP_001829931.1 NZ_CP073850:693055-693225 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200393 NZ_CP097840:1796620-1796886 [Shigella flexneri]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References