Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 681872..682381 Replicon chromosome
Accession NZ_CP073850
Organism Staphylococcus epidermidis strain B1266911

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV33_RS03535 Protein ID WP_001829980.1
Coordinates 682172..682381 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV33_RS03530 Protein ID WP_001829893.1
Coordinates 681872..682165 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV33_RS03505 (KFV33_03505) 676880..677668 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV33_RS03510 (KFV33_03510) 677674..678312 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV33_RS03515 (KFV33_03515) 678401..679273 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV33_RS03520 (KFV33_03520) 679379..680032 - 654 WP_001829983.1 HD domain-containing protein -
KFV33_RS03525 (KFV33_03525) 680214..681698 - 1485 WP_002457116.1 cardiolipin synthase -
KFV33_RS03530 (KFV33_03530) 681872..682165 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV33_RS03535 (KFV33_03535) 682172..682381 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV33_RS03540 (KFV33_03540) 682524..682661 + 138 WP_001829949.1 Lmo0850 family protein -
KFV33_RS03545 (KFV33_03545) 682761..683972 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV33_RS03550 (KFV33_03550) 684363..685436 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV33_RS03555 (KFV33_03555) 685448..686803 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200392 WP_001829980.1 NZ_CP073850:682172-682381 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200392 NZ_CP097840:1596146-1596460 [Shigella flexneri]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200392 WP_001829893.1 NZ_CP073850:681872-682165 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200392 NZ_CP097840:1596457-1596873 [Shigella flexneri]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References