Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2253899..2254369 Replicon chromosome
Accession NZ_CP073847
Organism Staphylococcus epidermidis strain B1266875

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV50_RS10960 Protein ID WP_001829569.1
Coordinates 2254181..2254369 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV50_RS13440 Protein ID WP_002438963.1
Coordinates 2253899..2254156 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV50_RS10925 (KFV50_10935) 2249263..2249979 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KFV50_RS10930 (KFV50_10940) 2250140..2250562 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV50_RS10935 (KFV50_10945) 2250746..2250901 - 156 WP_001829648.1 hypothetical protein -
KFV50_RS10940 (KFV50_10950) 2251487..2251987 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV50_RS10945 (KFV50_10955) 2252258..2252845 - 588 WP_001829615.1 histidine phosphatase family protein -
KFV50_RS10950 (KFV50_10960) 2253059..2253295 + 237 WP_002457224.1 hypothetical protein -
KFV50_RS10955 (KFV50_10965) 2253287..2253490 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV50_RS13440 2253899..2254156 + 258 WP_002438963.1 hypothetical protein Antitoxin
KFV50_RS10960 (KFV50_10970) 2254181..2254369 + 189 WP_001829569.1 hypothetical protein Toxin
KFV50_RS10965 (KFV50_10975) 2254559..2255113 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV50_RS10970 (KFV50_10980) 2255173..2255406 - 234 WP_001829664.1 hypothetical protein -
KFV50_RS10975 (KFV50_10985) 2255690..2256436 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV50_RS10980 (KFV50_10990) 2256535..2256819 + 285 WP_001829635.1 hypothetical protein -
KFV50_RS10985 (KFV50_10995) 2256843..2257067 + 225 WP_001829613.1 hypothetical protein -
KFV50_RS10990 (KFV50_11000) 2257688..2257888 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2244871..2269155 24284
- flank IS/Tn - - 2250746..2250901 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200390 WP_001829569.1 NZ_CP073847:2254181-2254369 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200390 NZ_CP097840:1155662-1155769 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200390 WP_002438963.1 NZ_CP073847:2253899-2254156 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200390 NZ_CP097840:c1155605-1155550 [Shigella flexneri]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References