Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2039373..2039882 Replicon chromosome
Accession NZ_CP073847
Organism Staphylococcus epidermidis strain B1266875

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV50_RS09780 Protein ID WP_001829980.1
Coordinates 2039373..2039582 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV50_RS09785 Protein ID WP_001829893.1
Coordinates 2039589..2039882 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV50_RS09760 (KFV50_09770) 2034951..2036306 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KFV50_RS09765 (KFV50_09775) 2036318..2037391 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV50_RS09770 (KFV50_09780) 2037782..2038993 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV50_RS09775 (KFV50_09785) 2039093..2039230 - 138 WP_001829949.1 Lmo0850 family protein -
KFV50_RS09780 (KFV50_09790) 2039373..2039582 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV50_RS09785 (KFV50_09795) 2039589..2039882 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV50_RS09790 (KFV50_09800) 2040056..2041540 + 1485 WP_002457116.1 cardiolipin synthase -
KFV50_RS09795 (KFV50_09805) 2041722..2042375 + 654 WP_001829983.1 HD domain-containing protein -
KFV50_RS09800 (KFV50_09810) 2042481..2043353 - 873 WP_002458703.1 membrane protein insertase YidC -
KFV50_RS09805 (KFV50_09815) 2043442..2044080 - 639 WP_002505076.1 thiamine phosphate synthase -
KFV50_RS09810 (KFV50_09820) 2044086..2044874 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200389 WP_001829980.1 NZ_CP073847:c2039582-2039373 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200389 NZ_CP097840:1155179-1155286 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200389 WP_001829893.1 NZ_CP073847:c2039882-2039589 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200389 NZ_CP097840:c1155122-1155067 [Shigella flexneri]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References