Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 681787..682296 | Replicon | chromosome |
Accession | NZ_CP073844 | ||
Organism | Staphylococcus epidermidis strain B1265603 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | Q5HMD5 |
Locus tag | KFV41_RS03455 | Protein ID | WP_001829980.1 |
Coordinates | 682087..682296 (+) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | Q5HMD4 |
Locus tag | KFV41_RS03450 | Protein ID | WP_001829893.1 |
Coordinates | 681787..682080 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFV41_RS03425 (KFV41_03425) | 676795..677583 | + | 789 | WP_001829971.1 | hydroxyethylthiazole kinase | - |
KFV41_RS03430 (KFV41_03430) | 677589..678227 | + | 639 | WP_002505076.1 | thiamine phosphate synthase | - |
KFV41_RS03435 (KFV41_03435) | 678316..679188 | + | 873 | WP_002458703.1 | membrane protein insertase YidC | - |
KFV41_RS03440 (KFV41_03440) | 679294..679947 | - | 654 | WP_001829983.1 | HD domain-containing protein | - |
KFV41_RS03445 (KFV41_03445) | 680129..681613 | - | 1485 | WP_002457116.1 | cardiolipin synthase | - |
KFV41_RS03450 (KFV41_03450) | 681787..682080 | + | 294 | WP_001829893.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
KFV41_RS03455 (KFV41_03455) | 682087..682296 | + | 210 | WP_001829980.1 | heavy-metal-associated domain-containing protein | Toxin |
KFV41_RS03460 (KFV41_03460) | 682439..682576 | + | 138 | WP_001829949.1 | Lmo0850 family protein | - |
KFV41_RS03465 (KFV41_03465) | 682676..683887 | - | 1212 | WP_001829910.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
KFV41_RS03470 (KFV41_03470) | 684278..685351 | + | 1074 | WP_001832735.1 | D-alanine--D-alanine ligase | - |
KFV41_RS03475 (KFV41_03475) | 685363..686718 | + | 1356 | WP_001832734.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7987.24 Da Isoelectric Point: 7.0080
>T200382 WP_001829980.1 NZ_CP073844:682087-682296 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
Download Length: 210 bp
>T200382 NZ_CP097837:c4139128-4139021 [Shigella flexneri]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11070.65 Da Isoelectric Point: 5.5778
>AT200382 WP_001829893.1 NZ_CP073844:681787-682080 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
Download Length: 294 bp
>AT200382 NZ_CP097837:4139177-4139243 [Shigella flexneri]
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HWU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0N1EPA7 |