Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 467300..467770 Replicon chromosome
Accession NZ_CP073844
Organism Staphylococcus epidermidis strain B1265603

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV41_RS02275 Protein ID WP_001829569.1
Coordinates 467300..467488 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV41_RS13340 Protein ID WP_002438963.1
Coordinates 467513..467770 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV41_RS02245 (KFV41_02245) 463781..463981 + 201 WP_001829681.1 cold-shock protein -
KFV41_RS02250 (KFV41_02250) 464602..464826 - 225 WP_001829613.1 hypothetical protein -
KFV41_RS02255 (KFV41_02255) 464850..465134 - 285 WP_001829635.1 hypothetical protein -
KFV41_RS02260 (KFV41_02260) 465233..465979 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV41_RS02265 (KFV41_02265) 466263..466496 + 234 WP_001829664.1 hypothetical protein -
KFV41_RS02270 (KFV41_02270) 466556..467110 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV41_RS02275 (KFV41_02275) 467300..467488 - 189 WP_001829569.1 hypothetical protein Toxin
KFV41_RS13340 467513..467770 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV41_RS02280 (KFV41_02280) 468179..468382 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV41_RS02285 (KFV41_02285) 468374..468610 - 237 WP_002457224.1 hypothetical protein -
KFV41_RS02290 (KFV41_02290) 468824..469411 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV41_RS02295 (KFV41_02295) 469682..470182 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV41_RS02300 (KFV41_02300) 470786..470923 + 138 WP_162161215.1 hypothetical protein -
KFV41_RS02305 (KFV41_02305) 471107..471529 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV41_RS02310 (KFV41_02310) 471690..472406 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 470768..470923 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200381 WP_001829569.1 NZ_CP073844:c467488-467300 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200381 NZ_CP097837:c4138645-4138538 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200381 WP_002438963.1 NZ_CP073844:c467770-467513 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200381 NZ_CP097837:4138702-4138757 [Shigella flexneri]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References