Detailed information of TA system TA020038

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/-
• Location: 2761209..2761876
• Replicon: chromosome
• Accession: CP009789
• Organism: Escherichia coli K-12 strain ER3413

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: ER3413_2724
• Protein ID: AIZ52457.1
• Coordinates: 2761547..2761876 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: ER3413_2723
• Protein ID: AIZ52456.1
• Coordinates: 2761209..2761526 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER3413_2719	2757412..2759115	+	1704	AIZ52453.1	CP4-57 prophage; predicted inner membrane protein	-
ER3413_2721	2760013..2760471	+	459	AIZ52454.1	CP4-57 prophage; predicted antirestriction protein	-
ER3413_2722	2760480..2760962	+	483	AIZ52455.1	CP4-57 prophage; predicted DNA repair protein	-
ER3413_4561	2760971..2761171	+	201	AIZ54229.1	hypothetical protein	-
ER3413_2723	2761209..2761526	+	318	AIZ52456.1	CP4-57 prophage; antitoxin of the YpjF-YfjZ toxin-antitoxin system	Antitoxin
ER3413_2724	2761547..2761876	+	330	AIZ52457.1	CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system	Toxin
ER3413_2725	2762240..2766820	-	4581	AIZ52458.1	adhesin-like autotransporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12308.21 Da
• Isoelectric Point: 7.2761

>T20038 AIZ52457.1 CP009789:2761547-2761876 [Escherichia coli K-12]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T20038 CP009789:2761547-2761876 [Escherichia coli K-12]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11737.27 Da
• Isoelectric Point: 6.4630

>AT20038 AIZ52456.1 CP009789:2761209-2761526 [Escherichia coli K-12]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 318 bp

>AT20038 CP009789:2761209-2761526 [Escherichia coli K-12]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA