Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 467330..467800 Replicon chromosome
Accession NZ_CP073841
Organism Staphylococcus epidermidis strain B1264787

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV40_RS02275 Protein ID WP_001829569.1
Coordinates 467330..467518 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV40_RS13380 Protein ID WP_002438963.1
Coordinates 467543..467800 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV40_RS02245 (KFV40_02245) 463811..464011 + 201 WP_001829681.1 cold-shock protein -
KFV40_RS02250 (KFV40_02250) 464632..464856 - 225 WP_001829613.1 hypothetical protein -
KFV40_RS02255 (KFV40_02255) 464880..465164 - 285 WP_001829635.1 hypothetical protein -
KFV40_RS02260 (KFV40_02260) 465263..466009 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV40_RS02265 (KFV40_02265) 466293..466526 + 234 WP_001829664.1 hypothetical protein -
KFV40_RS02270 (KFV40_02270) 466586..467140 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV40_RS02275 (KFV40_02275) 467330..467518 - 189 WP_001829569.1 hypothetical protein Toxin
KFV40_RS13380 467543..467800 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV40_RS02280 (KFV40_02280) 468209..468412 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV40_RS02285 (KFV40_02285) 468404..468640 - 237 WP_002457224.1 hypothetical protein -
KFV40_RS02290 (KFV40_02290) 468854..469441 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV40_RS02295 (KFV40_02295) 469712..470212 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV40_RS02300 (KFV40_02300) 470798..470953 + 156 WP_001829648.1 hypothetical protein -
KFV40_RS02305 (KFV40_02305) 471137..471559 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV40_RS02310 (KFV40_02310) 471720..472436 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 470798..470953 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200376 WP_001829569.1 NZ_CP073841:c467518-467330 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200376 NZ_CP097837:c2565327-2565172 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200376 WP_002438963.1 NZ_CP073841:c467800-467543 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200376 NZ_CP097837:2565339-2565397 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References