200373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 691934..692463 Replicon chromosome
Accession NZ_CP073840
Organism Staphylococcus epidermidis strain B1264454

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KFV39_RS03590 Protein ID WP_001829891.1
Coordinates 692101..692463 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KFV39_RS03585 Protein ID WP_001829931.1
Coordinates 691934..692104 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV39_RS03560 (KFV39_03560) 687759..688238 + 480 WP_063278489.1 PH domain-containing protein -
KFV39_RS03565 (KFV39_03565) 688231..689736 + 1506 WP_001829976.1 PH domain-containing protein -
KFV39_RS03570 (KFV39_03570) 689723..690232 + 510 WP_001829888.1 PH domain-containing protein -
KFV39_RS03575 (KFV39_03575) 690280..690633 + 354 WP_001829915.1 holo-ACP synthase -
KFV39_RS03580 (KFV39_03580) 690699..691847 + 1149 WP_002468951.1 alanine racemase -
KFV39_RS03585 (KFV39_03585) 691934..692104 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFV39_RS03590 (KFV39_03590) 692101..692463 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KFV39_RS03595 (KFV39_03595) 692809..693810 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KFV39_RS03600 (KFV39_03600) 693910..694236 + 327 WP_001829952.1 anti-sigma factor antagonist -
KFV39_RS03605 (KFV39_03605) 694238..694678 + 441 WP_063278490.1 anti-sigma B factor RsbW -
KFV39_RS03610 (KFV39_03610) 694692..695462 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T200373 WP_001829891.1 NZ_CP073840:692101-692463 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T200373 NZ_CP097837:1907666-1907821 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT200373 WP_001829931.1 NZ_CP073840:691934-692104 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT200373 NZ_CP097837:c1907654-1907596 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References