200367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 681980..682489 Replicon chromosome
Accession NZ_CP073836
Organism Staphylococcus epidermidis strain B1262351

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KFV42_RS03460 Protein ID WP_001829980.1
Coordinates 682280..682489 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KFV42_RS03455 Protein ID WP_001829893.1
Coordinates 681980..682273 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV42_RS03430 (KFV42_03430) 676988..677776 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KFV42_RS03435 (KFV42_03435) 677782..678420 + 639 WP_002505076.1 thiamine phosphate synthase -
KFV42_RS03440 (KFV42_03440) 678509..679381 + 873 WP_002458703.1 membrane protein insertase YidC -
KFV42_RS03445 (KFV42_03445) 679487..680140 - 654 WP_001829983.1 HD domain-containing protein -
KFV42_RS03450 (KFV42_03450) 680322..681806 - 1485 WP_002457116.1 cardiolipin synthase -
KFV42_RS03455 (KFV42_03455) 681980..682273 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KFV42_RS03460 (KFV42_03460) 682280..682489 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KFV42_RS03465 (KFV42_03465) 682632..682769 + 138 WP_001829949.1 Lmo0850 family protein -
KFV42_RS03470 (KFV42_03470) 682869..684080 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
KFV42_RS03475 (KFV42_03475) 684471..685544 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KFV42_RS03480 (KFV42_03480) 685556..686911 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(4-95)


Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T200367 WP_001829980.1 NZ_CP073836:682280-682489 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T200367 NZ_CP097836:213370-213768 [Shigella flexneri]
ATGCTGAAGTTTATTCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAAAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCTGCAGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGGCTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAACTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT200367 WP_001829893.1 NZ_CP073836:681980-682273 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT200367 NZ_CP097836:213143-213370 [Shigella flexneri]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTAATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAGCGTCAGCACCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1


Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References