Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 467493..467963 Replicon chromosome
Accession NZ_CP073836
Organism Staphylococcus epidermidis strain B1262351

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KFV42_RS02280 Protein ID WP_001829569.1
Coordinates 467493..467681 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KFV42_RS13320 Protein ID WP_002438963.1
Coordinates 467706..467963 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV42_RS02245 (KFV42_02245) 462642..462842 + 201 WP_001829681.1 cold-shock protein -
KFV42_RS02250 (KFV42_02250) 463275..464447 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
KFV42_RS02255 (KFV42_02255) 464795..465019 - 225 WP_001829613.1 hypothetical protein -
KFV42_RS02260 (KFV42_02260) 465043..465327 - 285 WP_001829635.1 hypothetical protein -
KFV42_RS02265 (KFV42_02265) 465426..466172 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KFV42_RS02270 (KFV42_02270) 466456..466689 + 234 WP_001829664.1 hypothetical protein -
KFV42_RS02275 (KFV42_02275) 466749..467303 - 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KFV42_RS02280 (KFV42_02280) 467493..467681 - 189 WP_001829569.1 hypothetical protein Toxin
KFV42_RS13320 467706..467963 - 258 WP_002438963.1 hypothetical protein Antitoxin
KFV42_RS02285 (KFV42_02285) 468372..468575 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KFV42_RS02290 (KFV42_02290) 468567..468803 - 237 WP_002457224.1 hypothetical protein -
KFV42_RS02295 (KFV42_02295) 469017..469604 + 588 WP_001829615.1 histidine phosphatase family protein -
KFV42_RS02300 (KFV42_02300) 469875..470375 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
KFV42_RS02305 (KFV42_02305) 470961..471116 + 156 WP_001829648.1 hypothetical protein -
KFV42_RS02310 (KFV42_02310) 471300..471722 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
KFV42_RS02315 (KFV42_02315) 471883..472599 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463275..464447 1172
- flank IS/Tn - - 470961..471116 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-149)

Antitoxin

Vibrio phage ICP1, Orf50

(19-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T200366 WP_001829569.1 NZ_CP073836:c467681-467493 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T200366 NZ_CP097836:146586-147068 [Shigella flexneri]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT200366 WP_002438963.1 NZ_CP073836:c467963-467706 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT200366 NZ_CP097836:146293-146595 [Shigella flexneri]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References