Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 467493..467963 | Replicon | chromosome |
Accession | NZ_CP073836 | ||
Organism | Staphylococcus epidermidis strain B1262351 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | Q5HQS5 |
Locus tag | KFV42_RS02280 | Protein ID | WP_001829569.1 |
Coordinates | 467493..467681 (-) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | D4FNP2 |
Locus tag | KFV42_RS13320 | Protein ID | WP_002438963.1 |
Coordinates | 467706..467963 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFV42_RS02245 (KFV42_02245) | 462642..462842 | + | 201 | WP_001829681.1 | cold-shock protein | - |
KFV42_RS02250 (KFV42_02250) | 463275..464447 | + | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
KFV42_RS02255 (KFV42_02255) | 464795..465019 | - | 225 | WP_001829613.1 | hypothetical protein | - |
KFV42_RS02260 (KFV42_02260) | 465043..465327 | - | 285 | WP_001829635.1 | hypothetical protein | - |
KFV42_RS02265 (KFV42_02265) | 465426..466172 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
KFV42_RS02270 (KFV42_02270) | 466456..466689 | + | 234 | WP_001829664.1 | hypothetical protein | - |
KFV42_RS02275 (KFV42_02275) | 466749..467303 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
KFV42_RS02280 (KFV42_02280) | 467493..467681 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
KFV42_RS13320 | 467706..467963 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
KFV42_RS02285 (KFV42_02285) | 468372..468575 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
KFV42_RS02290 (KFV42_02290) | 468567..468803 | - | 237 | WP_002457224.1 | hypothetical protein | - |
KFV42_RS02295 (KFV42_02295) | 469017..469604 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
KFV42_RS02300 (KFV42_02300) | 469875..470375 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
KFV42_RS02305 (KFV42_02305) | 470961..471116 | + | 156 | WP_001829648.1 | hypothetical protein | - |
KFV42_RS02310 (KFV42_02310) | 471300..471722 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
KFV42_RS02315 (KFV42_02315) | 471883..472599 | + | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 463275..464447 | 1172 | |
- | flank | IS/Tn | - | - | 470961..471116 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T200366 WP_001829569.1 NZ_CP073836:c467681-467493 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T200366 NZ_CP097836:146586-147068 [Shigella flexneri]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATGACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT200366 WP_002438963.1 NZ_CP073836:c467963-467706 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT200366 NZ_CP097836:146293-146595 [Shigella flexneri]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0N0LUH8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0U5IVM3 |